Schültke, E.* ; Bayat, S.* ; Bartzsch, S. ; Bräuer-Krisch, E.* ; Djonov, V.* ; Fiedler, S.* ; Fernandez-Palomo, C.* ; Jaekel, F.* ; Pellicioli, P.* ; Trappetti, V.* ; Hildebrandt, G.*
A mouse model for microbeam radiation therapy of the lung.
Int. J. Radiat. Oncol. Biol. Phys. 110, 521-525 (2021)
Purpose: Radiation therapy is an important treatment component for patients with lung cancer. However, the survival time gained with clinical radiation therapy techniques is relatively short. Data from preclinical experiments suggest that synchrotron microbeam radiation therapy could be much better suited to control malignant brain tumors than current clinical concepts of radiation therapy. Even at peak doses of several hundred gray, the extent of functional deficits is low. Methods and Materials: We have developed the first mouse model to study the effects of microbeam irradiation in lung tissue. Results: Up to peak doses of 400 Gy, no acute adverse effects were seen. Conclusion: This model is well suited to explore the potential of microbeam radiation therapy in the treatment of lung cancer and the response of normal lung tissue and organs at risk.
Impact Factor
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Times Cited
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Radiotherapy; Uniform
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2021
Prepublished im Jahr
2020
HGF-Berichtsjahr
2020
ISSN (print) / ISBN
0360-3016
e-ISSN
0360-3016
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 110,
Heft: 2,
Seiten: 521-525
Artikelnummer: ,
Supplement: ,
Reihe
Verlag
Elsevier
Verlagsort
Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Radiation Sciences
PSP-Element(e)
G-501300-001
Förderungen
Deutsche Forschungsgemeinschaft (DFG) , Germany
Copyright
Erfassungsdatum
2021-02-12