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Leone, V. ; Ali, A.* ; Weber, A.* ; Tschaharganeh, D.F.* ; Heikenwalder, M.*

Liver inflammation and hepatobiliary cancers.

Trends Cancer 7, 606-623 (2021)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Immune regulation has an important role in cancer development, particularly in organs with continuous exposure to environmental pathogens, such as the liver and gastrointestinal tract. Chronic liver inflammation can lead to the development of hepatobiliary cancers, namely hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), or combined HCC (cHCC)-CCA. In this review, we discuss the link between oxidative stress and the hepatic immune compartments, as well as how these factors trigger hepatocyte damage, proliferation, and eventually cancer initiation and its sustainment. We further give an overview of new anticancer therapies based on immunomodulation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Hcc ; Chcc-cca ; Icca ; Inflammation ; Oxidative Stress; Yes-associated Protein; Causes Nonalcoholic Steatohepatitis; Oxidative Dna-damage; Hepatocellular-carcinoma; Intrahepatic Cholangiocarcinoma; Hepatitis-c; Intestinal Microbiota; Apoptotic Bodies; United-states; Kupffer Cells
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2405-8033
e-ISSN 2405-8025
Zeitschrift Trends in cancer
Quellenangaben Band: 7, Heft: 7, Seiten: 606-623 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Translational Metabolic Oncology (IDC-TMO)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501000-001
DOI 10.1016/j.trecan.2021.01.012
WOS ID WOS:000662229900006
Scopus ID 85101871663
PubMed ID 33674229
Erfassungsdatum 2021-04-27
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