Anatomical and cellular heterogeneity in the mouse oviduct- its potential roles in reproduction and preimplantation development.
Biol. Reprod. 104, 1249-1261 (2021)
The oviduct/fallopian tube is a tube-like structure that extends from the uterus to the ovary. It is an essential reproductive organ that provides an environment for internal fertilization and preimplantation development. However, our knowledge of its regional and cellular heterogeneity is still limited. Here, we examined the anatomical complexity of mouse oviducts using modern imaging techniques and fluorescence reporter lines. We found that there are consistent coiling patterns and turning points in the coiled mouse oviduct that serve as reliable landmarks for luminal morphological regionalities. We also found previously unrecognized anatomical structures in the isthmus and uterotubal junction (UTJ) that likely play roles in reproduction. Further, we demarcated the ampulla-isthmus junction (AIJ) as a distinct region. Taken together, the oviduct mucosal epithelium has highly diverse structures with distinct epithelial cell populations, reflecting its complex functions in reproduction.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Fallopian Tube ; Luminal Epithelium ; Luminal Folds ; Oviduct ; Preimplantation Development ; Sperm Reservoir; Common Marmoset; Sperm Reservoir; Epithelium; Endoderm; Features; Isthmus; Embryo; Cells
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2021
Prepublished im Jahr
HGF-Berichtsjahr
2021
ISSN (print) / ISBN
0006-3363
e-ISSN
1529-7268
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 104,
Heft: 6,
Seiten: 1249-1261
Artikelnummer: ,
Supplement: ,
Reihe
Verlag
Oxford University Press
Verlagsort
Journals Dept, 2001 Evans Rd, Cary, Nc 27513 Usa
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30201 - Metabolic Health
Forschungsfeld(er)
Helmholtz Diabetes Center
PSP-Element(e)
G-502300-001
Förderungen
Canderel graduate studentship
CCS innovation to Impact (i2I) Grant
Cancer Research Society Operation Grant
Centre for Research in Reproductuion and Development (CRRD)
Rolande & Marcel Gosselin graduate studentship
Canderel
CRRD
Fonds de recherche du Quebec - Sante (FRQS)
McGill Integrated Cancer Research Training (MICRTP) studentship
Canadian Cancer Society (CCS) Innovation Grant (Haladner Memorial Foundation)
Copyright
Erfassungsdatum
2021-05-17