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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
CD27 is required for protective lytic EBV antigen specific CD8+ T cell expansion.
Blood 137, 3225-3236 (2021)
Verlagsversion
Forschungsdaten
DOI
PMC
Primary immunodeficiencies in the co-stimulatory molecule CD27 and its ligand CD70 predispose for pathologies of uncontrolled Epstein Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27 positive cells and antibody blocking of CD27 interaction with CD70 causes uncontrolled EBV infection in mice with reconstituted human immune system components. While overall CD8+ T cell expansion and composition is unaltered after antibody blocking of CD27, only some EBV specific CD8+ T cell responses, exemplified by early lytic EBV antigen BMLF1 specific CD8+ T cells are inhibited in their proliferation and killing of EBV transformed B cells. This suggests that CD27 is not required for all CD8+ T cell expansions and cytotoxicity, but for a subset of CD8+ T cell responses that protect us from EBV infection.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
22.113
0.000
4
5
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Epstein-barr-virus; Linked Lymphoproliferative Disease; Natural-killer-cells; Combined Immunodeficiency; Cultured Lymphoblasts; Expression; Differentiation; Lymphoma; Humans; Family
Sprache
englisch
Veröffentlichungsjahr
2021
HGF-Berichtsjahr
2021
ISSN (print) / ISBN
0006-4971
e-ISSN
1528-0020
Zeitschrift
Blood
Quellenangaben
Band: 137,
Heft: 23,
Seiten: 3225-3236
Verlag
American Society of Hematology
Verlagsort
2021 L St Nw, Suite 900, Washington, Dc 20036 Usa
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Gene Vector (AGV)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e)
G-501500-001
WOS ID
WOS:000667997800007
PubMed ID
33827115
Erfassungsdatum
2021-05-28