Decoding the organization, dynamics, and function of the 4D genome.
Dev. Cell 56, 1562-1573 (2021)
Understanding how complex cell-fate decisions emerge at the molecular level is a key challenge in developmental biology. Despite remarkable progress in decoding the contribution of the linear epigenome, how spatial genome architecture functionally informs changes in gene expression remains unclear. In this review, we discuss recent insights in elucidating the molecular landscape of genome folding, emphasizing the multilayered nature of the 3D genome, its importance for gene regulation, and its spatiotemporal dynamics. Finally, we discuss how these new concepts and emergent technologies will enable us to address some of the outstanding questions in development and disease.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Typ der Hochschulschrift
Herausgeber
Schlagwörter
4d Genome ; Cell Identity ; Gene Regulation ; Nuclear Architecture; 3d Chromatin Architecture; Chromosome Conformation; Dna Methylation; Gene-expression; Domains; Landscape; Topology; Reveal; Reorganization; Principles
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2021
Prepublished im Jahr
HGF-Berichtsjahr
2021
ISSN (print) / ISBN
1534-5807
e-ISSN
1878-1551
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 56,
Heft: 11,
Seiten: 1562-1573
Artikelnummer: ,
Supplement: ,
Reihe
Verlag
Elsevier
Verlagsort
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
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Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
Institut(e)
Helmholtz Pioneer Campus (HPC)
POF Topic(s)
30204 - Cell Programming and Repair
Forschungsfeld(er)
Pioneer Campus
PSP-Element(e)
G-510004-001
Förderungen
Helmholtz-Gemeinschaft
DFG
Helmholtz Pioneer Campus
Copyright
Erfassungsdatum
2021-06-18