PuSH - Publikationsserver des Helmholtz Zentrums München: Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Esteve-Codina, A.* ; Hofer, T.P. ; Burggraf, D. ; Heiss-Neumann, M.S. ; Gesierich, W. ; Boland, A.* ; Olaso, R.* ; Bihoreau, M.T.* ; Deleuze, J.F.* ; Möller, W. ; Schmid, O. ; Soler Artigas, M.* ; Renner, K.* ; Hohlfeld, J.M.* ; Welte, T.* ; Fuehner, T.* ; Jerrentrup, L.* ; Koczulla, A.R.* ; Greulich, T.* ; Prasse, A.* ; Müller-Quernheim, J.* ; Gupta, S.* ; Brightling, C.* ; Subramanian, D.R.* ; Parr, D.G.* ; Kolsum, U.* ; Gupta, V.* ; Barta, I.* ; Döme, B.* ; Strausz, J.* ; Stendardo, M.* ; Piattella, M.* ; Boschetto, P.* ; Korzybski, D.* ; Gorecka, D.* ; Nowinski, A.* ; Dabad, M.* ; Fernández-Callejo, M.* ; Endesfelder, D. ; zu Castell, W. ; Hiemstra, P.S.* ; Venge, P.* ; Nößner, E. ; Griebel, T.* ; Heath, S.* ; Singh, D.* ; Gut, I.* ; Ziegler-Heitbrock, L.

Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes.

Sci. Rep. 11:12848 (2021)

Verlagsversion

DOI

PMC

	Open Access Gold

Abstract
Metriken
Zusatzinfos

Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory disease and the genes expressed within the lung are crucial to its pathophysiology. We have determined the RNAseq transcriptome of bronchial brush cells from 312 stringently defined ex-smoker patients. Compared to healthy controls there were for males 40 differentially expressed genes (DEGs) and 73 DEGs for females with only 26 genes shared. The gene ontology (GO) term "response to bacterium" was shared, with several different DEGs contributing in males and females. Strongly upregulated genes TCN1 and CYP1B1 were unique to males and females, respectively. For male emphysema (E)-dominant and airway disease (A)-dominant COPD (defined by computed tomography) the term "response to stress" was found for both sub-phenotypes, but this included distinct up-regulated genes for the E-sub-phenotype (neutrophil-related CSF3R, CXCL1, MNDA) and for the A-sub-phenotype (macrophage-related KLF4, F3, CD36). In E-dominant disease, a cluster of mitochondria-encoded (MT) genes forms a signature, able to identify patients with emphysema features in a confirmation cohort. The MT-CO2 gene is upregulated transcriptionally in bronchial epithelial cells with the copy number essentially unchanged. Both MT-CO2 and the neutrophil chemoattractant CXCL1 are induced by reactive oxygen in bronchial epithelial cells. Of the female DEGs unique for E- and A-dominant COPD, 88% were detected in females only. In E-dominant disease we found a pronounced expression of mast cell-associated DEGs TPSB2, TPSAB1 and CPA3. The differential genes discovered in this study point towards involvement of different types of leukocytes in the E- and A-dominant COPD sub-phenotypes in males and females.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

4.379

1.377