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Ajarem, J.S.* ; Maodaa, S.N.* ; El-Serehy, H.A.* ; Altoom, N.* ; Allam, A.A.* ; Hernandez-Bautista, R. ; Mahmoud, A.M.*

Anethum graveolens prevents liver and kidney injury, oxidative stress and inflammation in mice exposed to nicotine perinatally.

Coatings 11:838 (2021)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
Perinatal exposure to nicotine imbalances the redox status in newborns. This study investigated the effect of Anethum graveolens (dill) extract on oxidative stress and tissue injury in the liver and kidney of mice newborns exposed to nicotine perinatally. Pregnant mice received nicotine (0.25 mg/kg) on gestational day 12 to day 5 after birth and/or A. graveolens extract on gestational day 1 to day 15 after birth. Newborn mice exposed to nicotine showed multiple histopathological alterations in the kidney and liver, including inflammatory cell infiltration and degenerative changes. Nicotine exposure increased hepatic and renal reactive oxygen species (ROS), lipid peroxidation, tumor necrosis factor (TNF-α), interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS) (p < 0.001), and decreased antioxidant defenses (p < 0.001). A. graveolens supplementation significantly prevented liver and kidney injury, suppressed ROS generation (p < 0.001), lipid peroxidation (p < 0.001) and inflammatory response (p < 0.001), and enhanced antioxidant defenses. In addition, A. graveolens upregulated hepatic and renal Nrf2 and HO-1 mRNA and increased HO-1 activity in normal and nicotine-exposed mice. In conclusion, A. graveolens protects against perinatal nicotine-induced oxidative stress, inflammation and tissue injury in the liver and kidney of newborn mice. A. graveolens upregulated hepatic and renal Nrf2/HO-1 signaling and enhanced antioxidant defenses in mice.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cytokines ; Dill ; Nicotine ; Nrf2 ; Oxidative Stress ; Smoking; Dna-damage; Metabolism; Acid; Protects; Imbalance; Toxicity; Kinetics; Smoking
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2079-6412
e-ISSN 2079-6412
Zeitschrift Coatings
Quellenangaben Band: 11, Heft: 7, Seiten: , Artikelnummer: 838 Supplement: ,
Verlag MDPI
Verlagsort St Alban-anlage 66, Ch-4052 Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
Förderungen King Saud University, Riyadh, Saudi Arabia
DOI 10.3390/coatings11070838
WOS ID WOS:000676595100001
Scopus ID 85111107174
Erfassungsdatum 2021-08-06
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