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von Krüchten, R.* ; Lorbeer, R.* ; Schuppert, C.* ; Storz, C.* ; Mujaj, B.* ; Schulz, H. ; Kauczor, H.U.* ; Peters, A. ; Bamberg, F.* ; Karrasch, S. ; Schlett, C.L.*

Subclinical cardiac impairment relates to traditional pulmonary function test parameters and lung volume as derived from whole-body MRI in a population-based cohort study.

Sci. Rep. 11:16173 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 subjects underwent whole-body MRI and spirometry as part of the KORA-FF4 cohort study. Lung volumes derived semi-automatically using an in-house algorithm. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and residual volume were measured. Cardiac parameters derived from Cine-SSFP-sequence using cvi42, while left ventricle (LV) time-volume-curves were evaluated using pyHeart. Linear regression analyses assessed the relationships of cardiac parameters with PFT and MRI-based lung volumes. Mean age was 56.3 ± 9.2 years (57% males). LV and right ventricular (RV) end-diastolic-, end-systolic-, stroke volume, LV peak ejection- and early/late diastolic filling rate were associated with FEV1, FVC, and residual volume (excluding late diastolic filling rate with FEV1, LV end-systolic/stroke volume and RV end-diastolic/end-systolic volumes with residual volume). In contrast, LV end-diastolic volume (ß = − 0.14, p = 0.01), early diastolic filling rate (ß = − 0.11, p = 0.04), and LV/RV stroke volume (ß = − 0.14, p = 0.01; ß = − 0.11, p = 0.01) were inversely associated with MRI-based lung volume. Subclinical cardiac impairment was associated with reduced FEV1, FVC, and residual volume. Cardiac parameters decreased with increasing MRI-based lung volume contrasting the results of PFT.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Percent Emphysema; Disease; Echocardiography; Standardization; Dysfunction; Burden; Kora; Copd
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 11, Heft: 1, Seiten: , Artikelnummer: 16173 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-009
G-504000-010
G-501800-401
G-504090-001
Förderungen German Centre for Cardiovascular Disease Research (DZHK, Berlin, Germany)
German Centre for Diabetes Research (DZD, Neuherberg Germany)
German Research Foundation (DFG, Bonn, Germany)
State of Bavaria
Helmholtz Zentrum Munchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
Projekt DEAL
DOI 10.1038/s41598-021-95655-7
WOS ID WOS:000683506200091
Scopus ID 85112052375
PubMed ID 34373570
Erfassungsdatum 2021-09-20
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