PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Sun, R.* ; He, L.* ; Lee, H.* ; Glinka, A.* ; Andrésen, C.* ; Hübschmann, D.* ; Jeremias, I. ; Müller-Decker, K.* ; Pabst, C.* ; Niehrs, C.*

RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia.

Cell Rep. 36:109559 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Acute myeloid leukemia (AML) is a rapidly progressing cancer, for which chemotherapy remains standard treatment and additional therapeutic targets are requisite. Here, we show that AML cells secrete the stem cell growth factor R-spondin 2 (RSPO2) to promote their self-renewal and prevent cell differentiation. Although RSPO2 is a well-known WNT agonist, we reveal that it maintains AML self-renewal WNT independently, by inhibiting BMP receptor signaling. Autocrine RSPO2 signaling is also required to prevent differentiation and to promote self-renewal in normal hematopoietic stem cells as well as primary AML cells. Comprehensive datamining reveals that RSPO2 expression is elevated in patients with AML of poor prognosis. Consistently, inhibiting RSPO2 prolongs survival in AML mouse xenograft models. Our study indicates that in AML, RSPO2 acts as an autocrine BMP antagonist to promote cancer cell renewal and may serve as a marker for poor prognosis.
Impact Factor
Scopus SNIP
Scopus
Cited By
Altmetric
9.423
1.943
1
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Acute Myeloid Leukemia ; Bmp ; Drug Resistance ; Hspc ; Leukemia Stem Cell ; Macrophages ; Monocytes ; R-spondin ; Self-renewal ; Wnt; Acute Myelogenous Leukemia; Hematopoietic Stem-cells; Wnt/beta-catenin; Wnt; Gene; Differentiation; Expression; Proteins; Cancer; Receptor
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Zeitschrift Cell Reports
Quellenangaben Band: 36, Heft: 7, Seiten: , Artikelnummer: 109559 Supplement: ,
Verlag Cell Press
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Apoptosis in Hematopoietic Stem Cells (AHS)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-506600-001
Förderungen Deutsche Forschungsgemeinschaft (DFG)
Max-Eder Grant of the German Cancer Aid
Deutsche Forschungsgemeinschaft
DOI 10.1016/j.celrep.2021.109559
WOS ID WOS:000686356500022
Scopus ID 85112845054
PubMed ID 34407399
Erfassungsdatum 2021-09-21
[➜Korrektur melden]