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Kabiri, Y.* ; Fuhrmann, A. ; Becker, A. ; Jedermann, L. ; Eberhagen, C. ; König, A. ; Silva, T.B.* ; Borges, F.* ; Hauck, S.M. ; Michalke, B. ; Knolle, P.* ; Zischka, H.

Mitochondrial impairment by MitobloCK-6 inhibits liver cancer cell proliferation. 

Front. Cell Dev. Biol. 9:725474 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Augmenter of liver regeneration (ALR) is a critical multi-isoform protein with its longer isoform, located in the mitochondrial intermembrane space, being part of the mitochondrial disulfide relay system (DRS). Upregulation of ALR was observed in multiple forms of cancer, among them hepatocellular carcinoma (HCC). To shed light into ALR function in HCC, we used MitoBloCK-6 to pharmacologically inhibit ALR, resulting in profound mitochondrial impairment and cancer cell proliferation deficits. These effects were mostly reversed by supplementation with bioavailable hemin b, linking ALR function to mitochondrial iron homeostasis. Since many tumor cells are known for their increased iron demand and since increased iron levels in cancer are associated with poor clinical outcome, these results help to further advance the intricate relation between iron and mitochondrial homeostasis in liver cancer.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Mitochondria ; Hcc ; Disulfide Relay System ; Iron ; Heme; Sulfhydryl Oxidase; Intermembrane Space; Protein; Expression; Iron; Regeneration; Metabolism; Maturation; Sorafenib; Induction
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2296-634X
e-ISSN 2296-634X
Zeitschrift Frontiers in cell and developmental biology
Quellenangaben Band: 9, Heft: , Seiten: , Artikelnummer: 725474 Supplement: ,
Verlag Frontiers
Verlagsort Lausanne
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Toxicology and Pharmacology (TOX)
Institute of Health Economics and Health Care Management (IGM)
CF Metabolomics & Proteomics (CF-MPC)
Research Unit BioGeoChemistry and Analytics (BGC)
POF Topic(s) 30203 - Molecular Targets and Therapies
30202 - Environmental Health
Forschungsfeld(er) Enabling and Novel Technologies
Genetics and Epidemiology
Environmental Sciences
PSP-Element(e) G-505200-003
G-505200-001
G-505300-001
G-505700-001
G-504800-002
Förderungen FEDER/COMPETE
Foundation for Science and Technology (FCT)
European Unions Horizon 2020 Research and Innovation programme under the Marie Sklodowska-Curie Grant
DOI 10.3389/fcell.2021.725474
WOS ID WOS:000703078100001
Scopus ID 85116491049
PubMed ID 34616733
Erfassungsdatum 2021-10-18
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