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Behrend, S.J. ; Giotopoulou, G.A. ; Spella, M.* ; Stathopoulos, G.T.

A role for club cells in smoking-associated lung adenocarcinoma.

Eur. Respir. Rev. 30:210122 (2021)
Verlagsversion DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The cellular origin of lung adenocarcinoma remains a focus of intense research efforts. The marked cellular heterogeneity and plasticity of the lungs, as well as the vast variety of molecular subtypes of lung adenocarcinomas perplex the field and account for the extensive variability of experimental results. While most experts would agree on the cellular origins of other types of thoracic tumours, great controversy exists on the tumour-initiating cells of lung adenocarcinoma, since this histologic subtype of lung cancer arises in the distal pulmonary regions where airways and alveoli converge, occurs in smokers as well as nonsmokers, is likely caused by various environmental agents, and is marked by vast molecular and pathologic heterogeneity. Alveolar type II, club, and their variant cells have all been implicated in lung adenocarcinoma progeny and the lineage hierarchies in the distal lung remain disputed. Here we review the relevant literature in this rapidly expanding field, including results from mouse models and human studies. In addition, we present a case for club cells as cells of origin of lung adenocarcinomas that arise in smokers.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 0905-9180
e-ISSN 1600-0617
Zeitschrift European Respiratory Review
Quellenangaben Band: 30, Heft: 162, Seiten: , Artikelnummer: 210122 Supplement: ,
Verlag European Respiratory Society
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-501600-003
DOI 10.1183/16000617.0122-2021
WOS ID WOS:000769745400012
Scopus ID 85120152598
PubMed ID 34670807
Erfassungsdatum 2021-11-18
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