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Della Torre, S.* ; Benedusi, V.* ; Pepe, G.* ; Meda, C.* ; Rizzi, N.* ; Uhlenhaut, N.H. ; Maggi, A.*

Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α.

Nat. Commun. 12:6883 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
In female mammals, the cessation of ovarian functions is associated with significant metabolic alterations, weight gain, and increased susceptibility to a number of pathologies associated with ageing. The molecular mechanisms triggering these systemic events are unknown because most tissues are responsive to lowered circulating sex steroids. As it has been demonstrated that isoform alpha of the estrogen receptor (ERα) may be activated by both estrogens and amino acids, we test the metabolic effects of a diet enriched in specific amino acids in ovariectomized (OVX) mice. This diet is able to block the OVX-induced weight gain and fat deposition in the liver. The use of liver-specific ERα KO mice demonstrates that the hepatic ERα, through the control of liver lipid metabolism, has a key role in the systemic response to OVX. The study suggests that the liver ERα might be a valuable target for dietary treatments for the post-menopause.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Sex-differences; Fatty Liver; Er-alpha; Expression; Insulin; Activation; Survival
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 12, Heft: 1, Seiten: , Artikelnummer: 6883 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-501900-227
Förderungen Department of Pharmaceutical Sciences (DISFARM, University of Milan)
European Community (ERC-Advanced Grant Ways)
Cariplo Foundation
DOI 10.1038/s41467-021-27272-x
WOS ID WOS:000722866700017
PubMed ID 34824281
Erfassungsdatum 2021-12-10
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