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Horsch, M. ; Seeburg, PH.* ; Adler, T.* ; Aguilar-Pimentel, J.A. ; Becker, L.* ; Calzada-Wack, J.* ; Garrett, L. ; Götz, A. ; Hans, W. ; Higuchi, M.* ; Hölter, S.M. ; Naton, B. ; Prehn, C. ; Puk, O. ; Rácz, I.* ; Rathkolb, B.* ; Rozman, J.* ; Schrewe, A. ; Adamski, J. ; Busch, D.H.* ; Esposito, I.* ; Graw, J. ; Ivandic, B.* ; Klingenspor, M.* ; Klopstock, T.* ; Mempel, M. ; Ollert, M.* ; Schulz, S. ; Wolf, E.* ; Wurst, W. ; Zimmer, A.* ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Beckers, J.

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice.

J. Biol. Chem. 286, 18614-18622 (2011)
Verlagsversion DOI PMC
Open Access Gold
ADAR2, an RNA editing enzyme that converts specific adenosines to inosines in certain pre-mRNAs, often leading to amino acid substitutions in the encoded proteins, is mainly expressed in brain. Of all ADAR2-mediated edits, a single one in the pre-mRNA of the AMPA receptor subunit GluA2 is essential for survival. Hence, early postnatal death of mice lacking ADAR2 is averted when the critical edit is engineered into both GluA2 encoding Gria2 alleles. Adar2(-/-)/Gria2(R/R) mice display normal appearance and life span, but the general phenotypic effects of global lack of ADAR2 have remained unexplored. Here we have employed the Adar2(-/-)/Gria2(R/R) mouse line, and Gria2(R/R) mice as controls, to study the phenotypic consequences of loss of all ADAR2-mediated edits except the critical one in GluA2. Our extended phenotypic analysis covering ∼320 parameters identified significant changes related to absence of ADAR2 in behavior, hearing ability, allergy parameters and transcript profiles of brain.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter no keywords
Sprache englisch
Veröffentlichungsjahr 2011
HGF-Berichtsjahr 2011
ISSN (print) / ISBN 0021-9258
e-ISSN 1083-351X
Zeitschrift Journal of Biological Chemistry, The
Quellenangaben Band: 286, Heft: 21, Seiten: 18614-18622 Artikelnummer: , Supplement: ,
Verlag American Society for Biochemistry and Molecular Biology
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Developmental Genetics (IDG)
Institute of Pathology (PATH)
Institute of Epidemiology (EPI)
Institute of Lung Health and Immunity (LHI)
Research Unit Molecular Epidemiology (AME)
POF Topic(s) 30201 - Metabolic Health
30204 - Cell Programming and Repair
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health

30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
Enabling and Novel Technologies
PSP-Element(e) G-500600-004
G-500600-003
G-500600-001
G-505600-001
G-500500-001
G-500500-002
G-500300-001
G-503900-001
G-521200-001
FE 73991
G-504200-002
PubMed ID 21467037
DOI 10.1074/jbc.M110.200881
WOS ID WOS:000290785700033
Scopus ID 79956313243
Erfassungsdatum 2011-06-22
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