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Maier, L. ; von Krüchten, R.* ; Lorbeer, R.* ; Filler, J. ; Nattenmüller, J.* ; Thorand, B. ; Koenig, W.* ; Rathmann, W.* ; Bamberg, F.* ; Schlett, C.L.* ; Peters, A. ; Rospleszcz, S.

Distribution and associated factors of hepatic iron-A population-based imaging study.

Metabolites 11:871 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Hepatic iron overload can cause severe organ damage; therefore, an early diagnosis and the identification of potential risk factors is crucial. We aimed to investigate the sex-specific distribution of hepatic iron content (HIC) in a population-based cohort and identify relevant associated factors from a panel of markers. We analyzed N = 353 participants from a cross-sectional sample (KORA FF4) who underwent whole-body magnetic resonance imaging. HIC was assessed by single-voxel spectroscopy with a high-speed T2-corrected multi-echo technique. A large panel of markers, including anthropometric, genetic, and laboratory values, as well as behavioral risk factors were assessed. Relevant factors associated with HIC were identified by variable selection based on LASSO regression with bootstrap resampling. HIC in the study sample (mean age at examination: 56.0 years, 58.4% men) was significantly lower in women (mean ± SD: 39.2 ± 4.1 s-1) than in men (41.8 ± 4.7 s-1, p < 0.001). Relevant factors associated with HIC were HbA1c as well as prediabetes for men and visceral adipose tissue as well as age for women. Hepatic fat, alcohol consumption, and genetic risk score for iron levels were associated with HIC in both sexes. In conclusion, there are sex-specific associations of HIC with markers of body composition, glucose metabolism, and alcohol consumption.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Diabetes ; Hepatic Fat ; Hepatic Iron ; Magnetic Resonance Imaging ; Markers; Genome-wide Association; Fatty Liver-disease; Serum Ferritin; Hepcidin Transcription; Insulin Sensitivity; Overload; Risk; Quantification; Metabolism; Parameters
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2218-1989
e-ISSN 2218-1989
Zeitschrift Metabolites
Quellenangaben Band: 11, Heft: 12, Seiten: , Artikelnummer: 871 Supplement: ,
Verlag MDPI
Verlagsort St Alban-anlage 66, Ch-4052 Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-010
G-504000-002
G-504090-001
Förderungen Deutsche Forschungsgemeinschaft
DOI 10.3390/metabo11120871
WOS ID WOS:000735490200001
Scopus ID 85121728850
PubMed ID 34940629
Erfassungsdatum 2022-02-02
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