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Mejhert, N.* ; Gabriel, K.R.* ; Frendo-Cumbo, S.* ; Krahmer, N. ; Song, J.* ; Kuruvilla, L.* ; Chitraju, C.* ; Boland, S.* ; Jang, D.K.* ; von Grotthuss, M.* ; Costanzo, M.C.* ; Rydén, M.* ; Olzmann, J.A.* ; Flannick, J.* ; Burtt, N.P.* ; Farese, R.V.*

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology.

Dev. Cell 57, 387-397.e4 (2022)
Postprint Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Lipid droplets (LDs) are organelles of cellular lipid storage with fundamental roles in energy metabolism and cell membrane homeostasis. There has been an explosion of research into the biology of LDs, in part due to their relevance in diseases of lipid storage, such as atherosclerosis, obesity, type 2 diabetes, and hepatic steatosis. Consequently, there is an increasing need for a resource that combines datasets from systematic analyses of LD biology. Here, we integrate high-confidence, systematically generated human, mouse, and fly data from studies on LDs in the framework of an online platform named the “Lipid Droplet Knowledge Portal” (https://lipiddroplet.org/). This scalable and interactive portal includes comprehensive datasets, across a variety of cell types, for LD biology, including transcriptional profiles of induced lipid storage, organellar proteomics, genome-wide screen phenotypes, and ties to human genetics. This resource is a powerful platform that can be utilized to identify determinants of lipid storage.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter C16orf54 ; Inflammation ; Msrb3 ; Proteasome ; Protein Targeting ; Proximity Labeling ; Sterol Ester ; Triacylglycerol; Low-density-lipoprotein; Cholesterol; Gene; Acyltransferase; Expression; Proteomics; Childhood; Disease; Seipin
Sprache englisch
Veröffentlichungsjahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 1534-5807
e-ISSN 1878-1551
Zeitschrift Developmental Cell
Quellenangaben Band: 57, Heft: 3, Seiten: 387-397.e4 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-501900-221
Förderungen Aramont Fund for Emerging Science Research
NIH
Margareta af Ugglas Foundation
Knut & Alice Wallenberg Foundation
Swedish Research Council
ERC-SyG SPHERES
Novo Nordisk Foundation
Tripartite Immuno-metabolism Consortium
MSAM Consortium
MeRIAD Consortium
CIMED
Swedish Diabetes Foundation
Strategic Research Program in Diabetes at Karolinska Institutet
American Heart Association Predoctoral Fellowship
Howard Hughes Medical Institute
DOI 10.1016/j.devcel.2022.01.003
WOS ID WOS:000753657800010
Scopus ID 85123863277
PubMed ID 35134345
Erfassungsdatum 2022-02-08
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