PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Milek, M.* ; Moulla, Y.* ; Kern, M. ; Stroh, C.* ; Dietrich, A.* ; Schön, M.R.* ; Gärtner, D.* ; Lohmann, T.* ; Dressler, M.* ; Kovacs, P.* ; Stumvoll, M. ; Blüher, M. ; Guiu-Jurado, E.

Adipsin serum concentrations and adipose tissue expression in people with obesity and type 2 diabetes.

Int. J. Mol. Sci. 23:2222 (2022)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
(1) Adipsin is an adipokine that may link increased fat mass and adipose tissue dysfunction to obesity-related cardiometabolic diseases. Here, we investigated whether adipsin serum concentrations and adipose tissue (AT) adipsin mRNA expression are related to parameters of AT function, obesity and type 2 diabetes (T2D). (2) Methods: A cohort of 637 individuals with a wide range of age and body weight (Age: 18–85 years; BMI: 19–70 kg/m2 ) with (n = 237) or without (n = 400) T2D was analyzed for serum adipsin concentrations by ELISA and visceral (VAT) and subcutaneous (SAT) adipsin mRNA expression by RT-PCR. (3) Results: Adipsin serum concentrations were significantly higher in patients with T2D compared to normoglycemic individuals. We found significant positive univariate relationships of adipsin serum concentrations with age (r = 0.282, p < 0.001), body weight (r = 0.264, p<0.001), fasting plasma glucose (r = 0.136, p = 0.006) and leptin serum concentrations (r = 0.362, p < 0.001). Neither VAT nor SAT adipsin mRNA expression correlated with adipsin serum concentrations after adjusting for age, sex and BMI. Independent of T2D status, we found significantly higher adipsin expression in SAT compared to VAT (4) Conclusions: Our data suggest that adipsin serum concentrations are strongly related to obesity and age. However, neither circulating adipsin nor adipsin AT expression reflects parameters of impaired glucose or lipid metabolism in patients with obesity with or without T2D.
Impact Factor
Scopus SNIP
Scopus
Cited By
Altmetric
6.208
1.441
2
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Adipose Tissue ; Adipsin ; Obesity ; T2d; Complement Factor-d; Insulin-resistance; Macrophage Infiltration; Dysfunction; Adipokines; Adipocyte; Proteins; Weight; Leptin; System
Sprache englisch
Veröffentlichungsjahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 23, Heft: 4, Seiten: , Artikelnummer: 2222 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-506500-001
G-506501-001
Förderungen Deutsche Forschungsgemeinschaft
German Center for Diabetes Research
DOI 10.3390/ijms23042222
WOS ID WOS:000763610800001
Scopus ID 85124609950
PubMed ID 35216336
Erfassungsdatum 2022-06-27
[➜Korrektur melden]