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Ruiz Tejada Segura, M.L. ; Abou Moussa, E.* ; Garabello, E. ; Nakahara, T.S.* ; Makhlouf, M.* ; Mathew, L.S.* ; Wang, L.* ; Valle, F.* ; Huang, S.S.Y.* ; Mainland, J.D.* ; Caselle, M.* ; Osella, M.* ; Lorenz, S.* ; Reisert, J.* ; Logan, D.W.* ; Malnic, B.* ; Scialdone, A. ; Saraiva, L.R.*

A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell.

Cell Rep. 38:110547 (2022)
Postprint Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The sense of smell helps us navigate the environment, but its molecular architecture and underlying logic remain understudied. The spatial location of odorant receptor genes (Olfrs) in the nose is thought to be independent of the structural diversity of the odorants they detect. Using spatial transcriptomics, we create a genome-wide 3D atlas of the mouse olfactory mucosa (OM). Topographic maps of genes differentially expressed in space reveal that both Olfrs and non-Olfrs are distributed in a continuous and overlapping fashion over at least five broad zones in the OM. The spatial locations of Olfrs correlate with the mucus solubility of the odorants they recognize, providing direct evidence for the chromatographic theory of olfaction. This resource resolves the molecular architecture of the mouse OM and will inform future studies on mechanisms underlying Olfr gene choice, axonal pathfinding, patterning of the nervous system, and basic logic for the peripheral representation of smell.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cp: Neuroscience ; Machine Learning ; Odorant ; Olfaction ; Olfactory Epithelium ; Olfactory Mucosa ; Rna-seq ; Spatial Transcriptomics
Sprache englisch
Veröffentlichungsjahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Zeitschrift Cell Reports
Quellenangaben Band: 38, Heft: 12, Seiten: , Artikelnummer: 110547 Supplement: ,
Verlag Cell Press
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
Institute of Functional Epigenetics (IFE)
Institute of Computational Biology (ICB)
POF Topic(s) 30204 - Cell Programming and Repair
30203 - Molecular Targets and Therapies
30205 - Bioengineering and Digital Health
Forschungsfeld(er) Stem Cell and Neuroscience
Helmholtz Diabetes Center
Enabling and Novel Technologies
PSP-Element(e) G-506290-001
G-502800-001
G-503800-001
Förderungen NIDCD NIH HHS
NIH HHS
DOI 10.1016/j.celrep.2022.110547
WOS ID WOS:000776076000006
Scopus ID 85126685016
PubMed ID 35320714
Erfassungsdatum 2022-05-09
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