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Scaltsoyiannes, V.* ; Corre, N.* ; Waltz, F. ; Giegé, P.*

Types and functions of mitoribosome-specific ribosomal proteins across eukaryotes.

Int. J. Mol. Sci. 23:3474 (2022)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Mitochondria are key organelles that combine features inherited from their bacterial endosymbiotic ancestor with traits that arose during eukaryote evolution. These energy producing organelles have retained a genome and fully functional gene expression machineries including specific ribosomes. Recent advances in cryo-electron microscopy have enabled the characterization of a fast-growing number of the low abundant membrane-bound mitochondrial ribosomes. Surprisingly, mitoribosomes were found to be extremely diverse both in terms of structure and composition. Still, all of them drastically increased their number of ribosomal proteins. Interestingly, among the more than 130 novel ribosomal proteins identified to date in mitochondria, most of them are composed of a-helices. Many of them belong to the nuclear encoded super family of helical repeat proteins. Here we review the diversity of functions and the mode of action held by the novel mitoribosome proteins and discuss why these proteins that share similar helical folds were independently recruited by mitoribosomes during evolution in independent eukaryote clades.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Helical Repeat Proteins ; Mitochondrial Gene Expression ; Pentatricopeptide Repeat Proteins ; Ribosomes ; Single Particle Cryo-em ; Translation
Sprache englisch
Veröffentlichungsjahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 23, Heft: 7, Seiten: , Artikelnummer: 3474 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Pioneer Campus (HPC)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Pioneer Campus
PSP-Element(e) G-510008-001
Förderungen Agence Nationale de la Recherche
DOI 10.3390/ijms23073474
WOS ID WOS:000781823200001
Scopus ID 85126849193
PubMed ID 35408834
Erfassungsdatum 2022-07-22
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