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möglich sobald bei der ZB eingereicht worden ist.
DNA copy number alterations in radiation-induced thyroid cancer.
Clin. Oncol. 23, 289-296 (2011)
For many years, gene alterations of the mitogen activated protein kinase pathway have been investigated in papillary thyroid carcinomas (PTC) and the radiation-specific induction of Ret/PTC rearrangements has been discussed in the published literature. According to recent studies, these alterations are now considered as age-related changes rather than radiation-specific changes in PTC. Thus, there is a strong motivation to search for novel alterations that might represent radiation-specific markers in PTC. DNA copy number alterations (CNAs) are frequent in human cancers and are also prevalent in PTC. However, the only way to tease out radiation-specific CNAs is a comparative analysis of CNAs from closely matched tumour cohorts, as various factors such as the age of patients or the histology of tumours also influence the type and frequency of CNA. Therefore, this review focuses on the current knowledge on CNAs in PTC and on future strategies to identify radiation-specific changes in these tumours.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
2.294
1.171
5
10
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Array CGH; CGH; Chernobyl; genomic copy number; thyroid cancer
Sprache
englisch
Veröffentlichungsjahr
2011
HGF-Berichtsjahr
2011
ISSN (print) / ISBN
0936-6555
e-ISSN
1433-2981
Zeitschrift
Clinical Oncology
Quellenangaben
Band: 23,
Heft: 4,
Seiten: 289-296
Verlag
Elsevier
Verlagsort
Amsterdam [u.a.]
Begutachtungsstatus
Peer reviewed
Institut(e)
Translational Metabolic Oncology (IDC-TMO)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Radiation Sciences
PSP-Element(e)
G-501000-001
Scopus ID
79955039547
PubMed ID
21316205
Erfassungsdatum
2011-09-07