PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Fox, E.R.* ; Young, J.H.* ; Li, Y.* ; Dreisbach, A.W.* ; Keating, B.J.* ; Musani, S.K.* ; Liu, K.* ; Morrison, A.C.* ; Ganesh, S.* ; Kutlar, A.* ; Ramachandran, V.S.* ; Polak, J.F.* ; Fabsitz, R.R.* ; Dries, D.L.* ; Farlow, D.N.* ; Redline, S.* ; Adeyemo, A.* ; Hirschhorn, J.N.* ; Sun, Y.V.* ; Wyatt, S.B.* ; Penman, A.D.* ; Palmas, W.* ; Rotter, J.I.* ; Townsend, R.R.* ; Doumatey, A.P.* ; Tayo, B.O.* ; Mosley, T.H Jr.* ; Lyon, H.N.* ; Kang, S.J.* ; Rotimi, C.N.* ; Cooper, R.S.* ; Franceschini, N.* ; Curb, J.D.* ; Martin, L.W.* ; Eaton, C.B.* ; Kardia, S.L.* ; Taylor, H.A.* ; Caulfield, M.J.* ; Ehret, GB.* ; Johnson, T.* ; ICBP Consortium (Meitinger, T. ; Wichmann, H.-E.) ; Chakravarti, A.* ; Zhu, X.* ; Levy, D.*

Association of genetic variation with systolic and diastolic blood pressure among African Americans: The Candidate Gene Association Resource study.

Hum. Mol. Genet. 20, 2273-2284 (2011)
Verlagsversion Volltext DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10(-8)) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10(-8)). The top IBC association for SBP was rs2012318 (P= 6.4 × 10(-6)) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10(-6)) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
8.058
1.654
91
137
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter genome-wide association; hypertension prevalence; receptor; disease; family; loci; vasculature; awareness; traits; design
Sprache englisch
Veröffentlichungsjahr 2011
HGF-Berichtsjahr 2011
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Zeitschrift Human Molecular Genetics
Quellenangaben Band: 20, Heft: 11, Seiten: 2273-2284 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford, UK
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Human Genetics (IHG)
Institute of Genetic Epidemiology (IGE)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500700-001
G-504100-001
PubMed ID 21378095
DOI 10.1093/hmg/ddr092
Erfassungsdatum 2011-09-08
[➜Korrektur melden]