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möglich sobald bei der ZB eingereicht worden ist.
HIV-1 Nef increases astrocyte sensitivity towards exogenous hydrogen peroxide.
Virol. J. 8:35 (2011)
BACKGROUND: HIV-1 infected individuals are under chronic exposure to reactive oxygen species (ROS) considered to be instrumental in the progression of AIDS and the development of HIV-1 associated dementia (HAD). Astrocytes support neuronal function and protect them against cytotoxic substances including ROS. The protein HIV-1 Nef, a progression factor in AIDS pathology is abundantly expressed in astrocytes in patients with HAD, and thus may influence its functions. RESULTS: Endogenous expressed HIV-1 Nef leads to increased sensitivity of human astrocytes towards exogenous hydrogen peroxide but not towards TNF-alpha. Cell death of nef-expressing astrocytes exposed to 10 μM hydrogen peroxide for 30 min occurred within 4 h. CONCLUSION: HIV-1 Nef may contribute to neuronal dysfunction and the development of HAD by causing death of astrocytes through decreasing their tolerance for hydrogen peroxide.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
2.546
0.988
7
14
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Human-immunodeficiency-virus; Cental-nervous-system; Aids-like disease; Oxidative stress; Cell-death; Chemottractant protein-1; Glutathione-peroxidase-peroxidase; Potential mechanism; Dependent manner; Transgenic mice
Sprache
englisch
Veröffentlichungsjahr
2011
HGF-Berichtsjahr
2011
e-ISSN
1743-422x
Zeitschrift
Virology Journal
Quellenangaben
Band: 8,
Artikelnummer: 35
Verlag
BioMed Central
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Virology (VIRO)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e)
G-502700-002
PubMed ID
21255447
Erfassungsdatum
2011-09-20