PuSH - Publikationsserver des Helmholtz Zentrums München: Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Reichart, D.* ; Lindberg, E.L.* ; Maatz, H.* ; Miranda, A.M.A.* ; Viveiros, A.* ; Shvetsov, N.* ; Gärtner, A.* ; Nadelmann, E.R.* ; Lee, M.* ; Kanemaru, K.* ; Ruiz-Orera, J.* ; Strohmenger, V.* ; DeLaughter, D.M.* ; Patone, G.* ; Zhang, H.* ; Woehler, A.* ; Lippert, C.* ; Kim, Y.* ; Adami, E.* ; Gorham, J.M.* ; Barnett, S.N.* ; Brown, K.* ; Buchan, R.J.* ; Chowdhury, R.A.* ; Constantinou, C.* ; Cranley, J.* ; Felkin, L.E.* ; Fox, H.* ; Ghauri, A.* ; Gummert, J.* ; Kanda, M.* ; Li, R.* ; Mach, L.* ; McDonough, B.* ; Samari, S.* ; Shahriaran, F. ; Yapp, C.* ; Stanasiuk, C.* ; Theotokis, P.I.* ; Theis, F.J. ; van den Bogaerdt, A.* ; Wakimoto, H.* ; Ware, J.S.* ; Worth, C.L.* ; Barton, P.J.R.* ; Lee, Y.A.* ; Teichmann, S.A.* ; Milting, H.* ; Noseda, M.* ; Oudit, G.Y.* ; Heinig, M. ; Seidman, J.G.* ; Hubner, N.* ; Seidman, C.E.*

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.

Science 377:eabo1984 (2022)

Verlagsversion

Postprint

Forschungsdaten

DOI

PMC

	Open Access Green

Abstract
Metriken
Zusatzinfos

Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) convey high risks for the development of heart failure through unknown mechanisms. Using single-nucleus RNA sequencing, we characterized the transcriptome of 880,000 nuclei from 18 control and 61 failing, nonischemic human hearts with pathogenic variants in DCM and ACM genes or idiopathic disease. We performed genotype-stratified analyses of the ventricular cell lineages and transcriptional states. The resultant DCM and ACM ventricular cell atlas demonstrated distinct right and left ventricular responses, highlighting genotype-associated pathways, intercellular interactions, and differential gene expression at single-cell resolution. Together, these data illuminate both shared and distinct cellular and molecular architectures of human heart failure and suggest candidate therapeutic targets.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

63.714

0.000