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Afghani, J. ; Traidl-Hoffmann, C. ; Schmitt-Kopplin, P. ; Reiger, M. ; Müller, C.

An overview of the latest metabolomics studies on atopic eczema with new directions for study.

Int. J. Mol. Sci. 23:8791 (2022)

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Atopic eczema (AE) is an inflammatory skin disorder affecting approximately 20% of children worldwide and early onset can lead to asthma and allergies. Currently, the mechanisms of the disease are not fully understood. Metabolomics, the analysis of small molecules in the skin produced by the host and microbes, opens a window to observe the mechanisms of the disease which then may lead to new drug targets for AE treatment. Here, we review the latest advances in AE metabolomics, highlighting both the lipid and non-lipid molecules, along with reviewing the metabolites currently known to reside in the skin.

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