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Scherer, J.* ; Nolden, M.* ; Kleesiek, J.* ; Metzger, J.* ; Kades, K.* ; Schneider, V.* ; Bach, M.* ; Sedlaczek, O.* ; Bucher, A.M.* ; Vogl, T.J.* ; Grünwald, F.* ; Kühn, J.P.* ; Hoffmann, R.T.* ; Kotzerke, J.* ; Bethge, O.* ; Schimmöller, L.* ; Antoch, G.* ; Müller, H.W.* ; Daul, A.* ; Nikolaou, K.* ; la Fougère, C.* ; Kunz, W.G.* ; Ingrisch, M.* ; Schachtner, B.* ; Ricke, J.* ; Bartenstein, P.* ; Nensa, F.* ; Radbruch, A.* ; Umutlu, L.* ; Forsting, M.* ; Seifert, R.* ; Herrmann, K.* ; Mayer, P.* ; Kauczor, H.U.* ; Penzkofer, T.* ; Hamm, B.* ; Brenner, W.* ; Kloeckner, R.* ; Düber, C.* ; Schreckenberger, M.* ; Braren, R.* ; Kaissis, G.* ; Makowski, M.* ; Eiber, M.* ; Gafita, A.* ; Trager, R.* ; Weber, W.A.* ; Neubauer, J.* ; Reisert, M.* ; Bock, M.* ; Bamberg, F.* ; Hennig, J.* ; Meyer, P.T.* ; Ruf, J.* ; Haberkorn, U.* ; Schoenberg, S.O.* ; Kuder, T.* ; Neher, P.* ; Floca, R.O.* ; Schlemmer, H.P.* ; Maier-Hein, K.*

Joint imaging platform for federated clinical data analytics.

JCO Clin. Can. Inform. 4, 1027-1038 (2020)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
PURPOSE: Image analysis is one of the most promising applications of artificial intelligence (AI) in health care, potentially improving prediction, diagnosis, and treatment of diseases. Although scientific advances in this area critically depend on the accessibility of large-volume and high-quality data, sharing data between institutions faces various ethical and legal constraints as well as organizational and technical obstacles. METHODS: The Joint Imaging Platform (JIP) of the German Cancer Consortium (DKTK) addresses these issues by providing federated data analysis technology in a secure and compliant way. Using the JIP, medical image data remain in the originator institutions, but analysis and AI algorithms are shared and jointly used. Common standards and interfaces to local systems ensure permanent data sovereignty of participating institutions. RESULTS: The JIP is established in the radiology and nuclear medicine departments of 10 university hospitals in Germany (DKTK partner sites). In multiple complementary use cases, we show that the platform fulfills all relevant requirements to serve as a foundation for multicenter medical imaging trials and research on large cohorts, including the harmonization and integration of data, interactive analysis, automatic analysis, federated machine learning, and extensibility and maintenance processes, which are elementary for the sustainability of such a platform. CONCLUSION: The results demonstrate the feasibility of using the JIP as a federated data analytics platform in heterogeneous clinical information technology and software landscapes, solving an important bottleneck for the application of AI to large-scale clinical imaging data.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 2473-4276
e-ISSN 2473-4276
Zeitschrift JCO Clinical Cancer Informatics
Quellenangaben Band: 4, Heft: , Seiten: 1027-1038 Artikelnummer: , Supplement: ,
Verlag American Society of Clinical Oncology
Verlagsort Alexandria
Institut(e) Helmholtz Artifical Intelligence Cooperation Unit (HAICU)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-530014-001
DOI 10.1200/CCI.20.00045
PubMed ID 33166197
Erfassungsdatum 2022-09-13
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