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Kaplan, L.* ; Drexler, C.G.* ; Pfaller, A.M.* ; Brenna, S.* ; Wunderlich, K.A.* ; Dimitracopoulos, A.* ; Merl-Pham, J. ; Perez, M.T.* ; Schlötzer-Schrehardt, U.* ; Enzmann, V.* ; Samardzija, M.* ; Puig, B.* ; Fuchs, P.* ; Franze, K.* ; Hauck, S.M. ; Grosche, A.*

Retinal regions shape human and murine Müller cell proteome profile and functionality.

Glia 71, 391-414 (2023)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We compared proteomic data from cone- and rod-rich retinae from human and mice and identified different expression profiles of cone- and rod-associated Müller cells that converged on pathways representing extracellular matrix and cell adhesion. In particular, epiplakin (EPPK1), which is thought to play a role in intermediate filament organization, was highly expressed in macular Müller cells. Furthermore, EPPK1 knockout in a human Müller cell-derived cell line led to a decrease in traction forces as well as to changes in cell size, shape, and filopodia characteristics. We here identified EPPK1 as a central molecular player in the region-specific architecture of the human retina, which likely enables specific functions under the immense mechanical loads in vivo.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Eppk1 ; Müller Cells ; Glial Heterogeneity ; Macula ; Retina; Glial-cells; Epiplakin; Expression; Keratin; Acid; Rna; Identification; Accumulation; Software; Proteins
Sprache englisch
Veröffentlichungsjahr 2023
Prepublished im Jahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 0894-1491
e-ISSN 1098-1136
Zeitschrift Glia
Quellenangaben Band: 71, Heft: 2, Seiten: 391-414 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Begutachtungsstatus Peer reviewed
Institut(e) CF Metabolomics & Proteomics (CF-MPC)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505700-001
A-630700-001
Förderungen Deutsche Forschungsgemeinschaft
ProRetina Foundation Germany
Austrian Science Fund
DOI 10.1002/glia.24283
WOS ID 000879083500001
WOS ID WOS:000879083500001
Scopus ID 85141475483
PubMed ID 36334068
Erfassungsdatum 2022-12-03
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