PuSH - Publikationsserver des Helmholtz Zentrums München: Aqp5<sup>--</sup>/<sup>--</sup> mice exhibit reduced maximal O2 consumption under cold exposure, normal pulmonary gas exchange, and impaired formation of brown adipose tissue.

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Al-Samir, S.* ; Yildirim, A.Ö. ; Sidhaye, V.K.* ; King, L.S.* ; Breves, G.* ; Conlon, T.M. ; Stoeger, C. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Gros, G.* ; Endeward, V.*

Aqp5^--/^-- mice exhibit reduced maximal O2 consumption under cold exposure, normal pulmonary gas exchange, and impaired formation of brown adipose tissue.

Am. J. Physiol.-Regul. Integr. Comp. Physiol. 324, R109-R119 (2022)

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The fundamental body functions that determine maximal O₂ uptake (V_O2,max) have not been studied in Aqp5 ^--/^-- (aquaporin 5, AQP5) mice. We measured V_O2,max to globally assess these functions and then investigated why it was found altered in Aqp5 ^--/^-- mice. V_O2,max was measured by the Helox technique, which elicits maximal metabolic rate by intense cold exposure of the animals. We found V_O2,max reduced in Aqp5 ^--/^-- mice by 20 - 30% compared to WT. Since AQP5 has been implicated to act as a membrane channel for respiratory gases, we studied whether this is due to the known lack of AQP5 in the alveolar epithelial membranes of Aqp5 ^--/^-- mice. Lung function parameters as well as arterial O₂ saturation were normal and identical between Aqp5 ^--/^-- and WT mice, indicating that AQP5 does not contribute to pulmonary O₂ exchange. The cause for the decreased V_O2,max thus might be found in decreased O₂ consumption of an intensely O₂-consuming peripheral organ such as activated BAT. We found indeed that absence of AQP5 greatly reduces the amount of interscapular BAT formed in response to 4 weeks' cold exposure, from 63% in WT to 25% in Aqp5 ^--/^-- animals. We conclude that lack of AQP5 does not affect pulmonary O₂ exchange, but greatly inhibits transformation of white to brown adipose tissue. Since under cold exposure BAT is a major source of the animals' heat production, reduction of BAT likely causes the decrease in V_O2,max under this condition.

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PuSH - Publikationsserver des Helmholtz Zentrums München

Aqp5--/-- mice exhibit reduced maximal O2 consumption under cold exposure, normal pulmonary gas exchange, and impaired formation of brown adipose tissue.

Aqp5^--/^-- mice exhibit reduced maximal O2 consumption under cold exposure, normal pulmonary gas exchange, and impaired formation of brown adipose tissue.