Divaret-Chauveau, A.* ; Mauny, F.* ; Hose, A.* ; Depner, M. ; Dalphin, M.L.* ; Kaulek, V.* ; Barnig, C.* ; Schaub, B.* ; Schmaußer-Hechfellner, E. ; Renz, H.* ; Riedler, J.* ; Pekkanen, J.* ; Karvonen, A.M.* ; Täubel, M.* ; Lauener, R.* ; Roduit, C.* ; Vuitton, D.A.* ; von Mutius, E. ; Demoulin-Alexikova, S.*
Trajectories of cough without a cold in early childhood and associations with atopic diseases.
Clin. Exp. Allergy 53, 429-442 (2022)
BACKGROUND: Although children can frequently experience a cough that affects their quality of life, few epidemiological studies have explored cough without a cold during childhood. OBJECTIVES: The objective of the study was to describe the latent class trajectories of cough from one to 10 years old and analyse their association with wheezing, atopy and allergic diseases. METHODS: Questions about cough, wheeze and allergic diseases were asked at 1, 1.5, 2, 3, 4, 5, 6 and 10 years of age in the European prospective cohort of Protection against Allergy: STUdy in Rural Environment (PASTURE). Specific IgE assays were performed at 10 years of age. Questions regarding a cough without a cold were used to build a latent class model of cough over time. RESULTS: Among the 961 children included in the study, apart from the never/infrequent trajectory (59.9%), eight trajectories of cough without a cold were identified: five grouped acute transient classes (24.1%), moderate transient (6.8%), late persistent (4.8%) and early persistent (4.4%). Compared with the never/infrequent trajectory, the other trajectories were significantly associated with wheezing, asthma and allergic rhinitis. For asthma, the strongest association was with the early persistent trajectory (ORa = 31.00 [14.03-68.51]), which was inversely associated with farm environment (ORa = 0.39 [0.19-0.77]) and had a high prevalence of cough triggers and unremitting wheeze. Late and early persistent trajectories were also associated with food allergy. Atopic sensitization was only associated with the late persistent trajectory. CONCLUSION: Late and early persistent coughs without a cold are positively associated with atopic respiratory diseases and food allergy. Children having recurrent cough without a cold with night cough and triggers would benefit from an asthma and allergy assessment. Growing up on a farm is associated with reduced early persistent cough.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Allergic Diseases ; Asthma ; Atopy ; Childhood ; Cough; Phenotypes; Mechanisms; Children; Wheeze; Asthma
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2022
Prepublished im Jahr
0
HGF-Berichtsjahr
2022
ISSN (print) / ISBN
0954-7894
e-ISSN
1365-2222
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 53,
Heft: 4,
Seiten: 429-442
Artikelnummer: ,
Supplement: ,
Reihe
Verlag
Wiley
Verlagsort
111 River St, Hoboken 07030-5774, Nj Usa
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Asthma and Allergy Prevention (IAP)
POF Topic(s)
30202 - Environmental Health
Forschungsfeld(er)
Allergy
PSP-Element(e)
G-503300-001
Förderungen
Copyright
Erfassungsdatum
2022-12-08