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Kundrát, P.* ; Friedland, W. ; Baiocco, G.*

Track structure-based simulations on DNA damage induced by diverse isotopes.

Int. J. Mol. Sci. 23:13693 (2022)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Diverse isotopes such as 2H, 3He, 10Be, 11C and 14C occur in nuclear reactions in ion beam radiotherapy, in cosmic ray shielding, or are intentionally accelerated in dating techniques. However, only a few studies have specifically addressed the biological effects of diverse isotopes and were limited to energies of several MeV/u. A database of simulations with the PARTRAC biophysical tool is presented for H, He, Li, Be, B and C isotopes at energies from 0.5 GeV/u down to stopping. The doses deposited to a cell nucleus and also the yields per unit dose of single- and double-strand breaks and their clusters induced in cellular DNA are predicted to vary among diverse isotopes of the same element at energies < 1 MeV/u, especially for isotopes of H and He. The results may affect the risk estimates for astronauts in deep space missions or the models of biological effectiveness of ion beams and indicate that radiation protection in 14C or 10Be dating techniques may be based on knowledge gathered with 12C or 9Be.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dna Damage ; Monte Carlo Simulations ; Analytical Functions ; Ionizing Radiation ; Isotopes ; Track Structure
Sprache englisch
Veröffentlichungsjahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 23, Heft: 22, Seiten: , Artikelnummer: 13693 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501391-001
Förderungen Università degli Studi di Pavia
Grantová Agentura České Republiky
Ministerstvo Školství, Mládeže a Tělovýchovy
Nuclear Physics Institute of the Czech Academy of Sciences
DOI 10.3390/ijms232213693
WOS ID WOS:000887364700001
Scopus ID 85142839675
PubMed ID 36430172
Erfassungsdatum 2022-12-09
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