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Kutscher, S. ; Bauer, T. ; Dembek, C.J. ; Sprinzl, M.F. ; Protzer, U.

Design of therapeutic vaccines: Hepatitis B as an example.

Microb. Biotechnol. 5, 270-282 (2012)
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Therapeutic vaccines are currently developed for chronic viral infections, such as human papillomavirus (HPV), human immunodeficiency virus (HIV), herpesvirus and hepatitis B (HBV) and C (HCV) virus infections. As an alternative to antiviral treatment or to support only partially effective therapy a therapeutic vaccine shall activate the patient's immune system to fight and finally control or ideally even eliminate the virus. Whereas the success of prophylactic vaccination is based on rapid neutralization of the invading pathogen by antibodies, virus control and elimination of infected cells require T cells. Therefore, induction of a multi-specific and multifunctional T-cell response against key viral antigens is a paradigm of therapeutic vaccination - besides activation of a humoral immune response to limit virus spread. In this review, we describe options to develop a therapeutic vaccine for chronic viral infections using HBV as a promising example.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter T-CELL RESPONSES; CHRONIC HBV INFECTION; TERM-FOLLOW-UP; VIRUS-INFECTION; SURFACE-ANTIGEN; IMMUNE-RESPONSE; CORE ANTIGEN; COMBINATION THERAPY; LYMPHOCYTE RESPONSE; GERMAN GUIDELINE
Sprache englisch
Veröffentlichungsjahr 2012
Prepublished im Jahr 2011
HGF-Berichtsjahr 2011
ISSN (print) / ISBN 1751-7907
e-ISSN 1751-7915
Zeitschrift Microbial Biotechnology
Quellenangaben Band: 5, Heft: 2, Seiten: 270-282 Artikelnummer: , Supplement: ,
Verlag Wiley
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
Institute of Molecular Immunology (IMI)
POF Topic(s) 30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-502700-003
G-520100-001
G-502700-004
G-501790-002
G-501790-001
G-501790-003
PubMed ID 21958338
DOI 10.1111/j.1751-7915.2011.00303.x
WOS ID WOS:000300675900013
Erfassungsdatum 2011-11-28
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