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Kleineidam, L.* ; Stark, M.* ; Riedel-Heller, S.G.* ; Pabst, A.* ; Schmiedek, F.* ; Streit, F.* ; Rietschel, M.* ; Klinger-König, J.* ; Grabe, H.J.* ; Erhardt, A.* ; Gelbrich, G.* ; Schmidt, B.* ; NAKO Investigators (Peters, A.) ; Berger, K.* ; Wagner, M.*

The assessment of cognitive function in the German National Cohort (NAKO) - Associations of demographics and psychiatric symptoms with cognitive test performance.

World J. Biol. Psychiatry, DOI: 10.1080/15622975.2021.2011408 (2022)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
OBJECTIVES: To describe the cognitive test battery of the German National Cohort (NAKO), a population-based mega cohort of 205,000 randomly selected participants, and to examine associations with demographic variables and selected psychiatric and neurological conditions. METHODS: Initial data from 96,401 participants providing data on the cognitive performance measured by a brief cognitive test battery (12-word list recall task, semantic fluency, Stroop test, digit span backwards) was examined. Test results were summarised in cognitive domain scores using exploratory and confirmatory factor analyses. Associations with sociodemographic and psychiatric factors were analysed using linear regression and generalised additive models. RESULTS: Cognitive test results were best represented by two domain scores reflecting memory and executive functions. Lower cognitive functions were associated with increasing age and male sex. Higher education and absence of childhood trauma were associated with better cognitive function. Moderate to severe levels of anxiety and depression, and a history of stroke, were related to lower cognitive function with a stronger effect on executive function as compared to memory. Some associations with cognition differed by German language proficiency. CONCLUSIONS: The NAKO cognitive test battery and the derived cognitive domain scores for memory and executive function are sensitive measures of cognition.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cognition ; German National Cohort ; Nako ; Cognitive Ageing ; Confirmatory Factor Analysis ; Depression
Sprache englisch
Veröffentlichungsjahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 1562-2975
e-ISSN 1814-1412
Zeitschrift The World Journal of Biological Psychiatry
Verlag Taylor & Francis
Verlagsort Abingdon
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-010
Förderungen Fresenius Medical Care North America
DOI 10.1080/15622975.2021.2011408
PubMed ID 35175181
Erfassungsdatum 2022-12-19
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