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Khajavi, N.* ; Beck, A.* ; Ricku, K.* ; Beyerle, P.* ; Jacob, K.* ; Syamsul, S.F.* ; Belkacemi, A.* ; Reinach, P.S.* ; Schreier, P.C.* ; Salah, H.* ; Popp, T.* ; Novikoff, A. ; Breit, A.* ; Chubanov, V.* ; Müller, T.D. ; Zierler, S.* ; Gudermann, T.*

TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.

JCI insight 8:e163397 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Most overweight individuals do not develop diabetes due to compensatory islet responses to restore glucose homeostasis. Therefore, regulatory pathways that promote β-cell compensation are potential targets for treatment of diabetes. The melastatin transient receptor potential 7 protein (TRPM7), harboring a cation channel and a serine/threonine kinase, has been implicated in controlling cell growth and proliferation. Here, we report that selective deletion of Trpm7 in β-cells disrupts insulin secretion and leads to progressive glucose intolerance. We indicate that the diminished insulinotropic response in β-cell-specific Trpm7 knockout mice is caused by decreased insulin production due to an impaired enzymatic activity of this protein. Accordingly, high-fat fed mice with a genetic loss of TRPM7 kinase activity (Trpm7R/R) display a marked glucose intolerance accompanied by hyperglycemia. These detrimental glucoregulatory effects are engendered by reduced compensatory β-cell responses due to mitigated AKT/ERK signaling. Collectively, our data identify TRPM7 kinase as a novel regulator of insulin synthesis, β-cell dynamics, and glucose homeostasis under obesogenic diet.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Beta Cells ; Cell Biology ; Insulin ; Ion Channels; Beta-cell-proliferation; Transcription Factor; Mass Expansion; Expression; Channels; Pdx1; Magnesium; Transactivator; Contributes; Hyperplasia
Sprache englisch
Veröffentlichungsjahr 2023
Prepublished im Jahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 2379-3708
e-ISSN 2379-3708
Zeitschrift JCI insight
Quellenangaben Band: 8, Heft: 3, Seiten: , Artikelnummer: e163397 Supplement: ,
Verlag Clarivate
Verlagsort Ann Arbor, Michigan
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
G-501900-221
Förderungen DFG
DZD
Deutsche Forschungsgemeinschaft (German Research Foundation, DFG)
DOI 10.1172/jci.insight.163397
WOS ID 000931706600001
Scopus ID 85147720414
PubMed ID 36574297
Erfassungsdatum 2023-01-10
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