PuSH - Publikationsserver des Helmholtz Zentrums München: Exercise-induced N-lactoylphenylalanine predicts adipose tissue loss during endurance training in overweight and obese humans.

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Hoene, M.* ; Zhao, X.* ; Machann, J. ; Birkenfeld, A.L. ; Heni, M. ; Peter, A. ; Niess, A.* ; Moller, A. ; Lehmann, R. ; Xu, G.* ; Weigert, C.

Exercise-induced N-lactoylphenylalanine predicts adipose tissue loss during endurance training in overweight and obese humans.

Metabolites 13:15 (2022)

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Physical exercise is a powerful measure to prevent cardiometabolic diseases. However, the individual response to lifestyle interventions is variable and cannot, to date, be predicted. N-Lactoylphenylalanine (Lac-Phe) produced during exercise has recently been shown to mediate weight loss in obese mice. Lac-Phe could also contribute to, and potentially explain differences in, the effectiveness of exercise interventions in humans. Sedentary overweight and obese subjects completed an 8-week supervised endurance exercise intervention (n = 22). Before and after the intervention, plasma levels of Lac-Phe were determined by UHPLC-MS in the resting state and immediately after an acute bout of endurance exercise. Adipose tissue volume was quantified using MRI. Acute exercise caused a pronounced increase in Lac-Phe, both before and after the intervention. Higher levels of Lac-Phe after acute exercise were associated with a greater reduction in abdominal subcutaneous and, to a lower degree, visceral adipose tissue during the intervention. Lac-Phe produced during physical activity could contribute to weight loss by acting as a signaling molecule that regulates food intake, as previously shown in mice. Quantification of Lac-Phe during an exercise test could be employed as a tool to predict and potentially improve the individual response to exercise-based lifestyle interventions in overweight humans and those with obesity.

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5.581

1.180