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Hansen, F.J.* ; David, P.* ; Akram, M.* ; Knoedler, S. ; Mittelstädt, A.* ; Merkel, S.* ; Podolska, M.J.* ; Swierzy, I.* ; Roßdeutsch, L.* ; Klösch, B.* ; Kouhestani, D.* ; Anthuber, A.* ; Bénard, A.* ; Brunner, M.* ; Krautz, C.* ; Grützmann, R.* ; Weber, G.F.*

Circulating monocytes serve as novel prognostic biomarker in pancreatic ductal adenocarcinoma patients.

Cancers 15:13 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Pancreatic ductal adenocarcinoma (PDAC) ranks among the most fatal cancer diseases, widely accepted to have the most dismal prognoses. Although immunotherapy has broadly revolutionized cancer treatment, its value in PDAC appears to be relatively low. Exhibiting protumoral effects, monocytes have recently been proposed as potential targets of such immunotherapeutic regimens. However, to date, the body of evidence on monocytes' role in PDAC is scarce. Therefore, we analyzed monocytes in the peripheral blood of 58 PDAC patients prior to surgery and compared them to healthy individuals. PDAC patients showed increased levels of monocytes when compared to healthy controls In addition, patients with perineural infiltration demonstrated a higher percentage of monocytes compared to non-infiltrating tumors and PDAC G3 was associated with higher monocyte levels than PDAC G2. Patients with monocyte levels > 5% were found to have an 8.9-fold increased risk for a G3 and perineural infiltrated PDAC resulting in poorer survival compared to patients with <5% monocyte levels. Furthermore, PDAC patients showed increased expressions of CD86 and CD11c and decreased expressions of PD-L1 on monocytes compared to healthy individuals. Finally, levels of monocytes correlated positively with concentrations of IL-6 and TNF-α in plasma of PDAC patients. Based on our findings, we propose monocytes as a novel prognostic biomarker. Large-scale studies are needed to further decipher the role of monocytes in PDAC and investigate their potential as therapeutic targets.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Grading ; Liquid Biopsy ; Monocytes ; Pancreatic Ductal Adenocarcinoma ; Perineural Invasion ; Prognostic Biomarker; Cancer; Survival; Lymphocyte; Aggressiveness; Macrophage; Ccr2
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2072-6694
Zeitschrift Cancers
Quellenangaben Band: 15, Heft: 2, Seiten: , Artikelnummer: 13 Supplement: ,
Verlag MDPI
Verlagsort St Alban-anlage 66, Ch-4052 Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology and Medicine (IRBM)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-509400-001
DOI 10.3390/cancers15020363
WOS ID 000914616500001
Scopus ID 85146572305
PubMed ID 36672313
Erfassungsdatum 2023-01-24
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