PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Micolucci, L.* ; Matacchione, G.* ; Albertini, M.C.* ; Marra, M.* ; Ramini, D.* ; Giuliani, A.* ; Sabbatinelli, J.* ; Procopio, A.D.* ; Olivieri, F.* ; Marsico, A. ; Monsurrò, V.*

A data-mining approach to identify NF-kB-responsive microRNAs in tissues involved in inflammatory processes: Potential relevance in age-related diseases.

Int. J. Mol. Sci. 24:26 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The nuclear factor NF-kB is the master transcription factor in the inflammatory process by modulating the expression of pro-inflammatory genes. However, an additional level of complexity is the ability to promote the transcriptional activation of post-transcriptional modulators of gene expression as non-coding RNA (i.e., miRNAs). While NF-kB's role in inflammation-associated gene expression has been extensively investigated, the interplay between NF-kB and genes coding for miRNAs still deserves investigation. To identify miRNAs with potential NF-kB binding sites in their transcription start site, we predicted miRNA promoters by an in silico analysis using the PROmiRNA software, which allowed us to score the genomic region's propensity to be miRNA cis-regulatory elements. A list of 722 human miRNAs was generated, of which 399 were expressed in at least one tissue involved in the inflammatory processes. The selection of "high-confidence" hairpins in miRbase identified 68 mature miRNAs, most of them previously identified as inflammamiRs. The identification of targeted pathways/diseases highlighted their involvement in the most common age-related diseases. Overall, our results reinforce the hypothesis that persistent activation of NF-kB could unbalance the transcription of specific inflammamiRNAs. The identification of such miRNAs could be of diagnostic/prognostic/therapeutic relevance for the most common inflammatory-related and age-related diseases.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Altmetric
5.600
0.000
2
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Nf-kb ; Data-mining ; Inflammation ; Micrornas; Mirna-target Interactions; Dna Helicase Activity; Kappa-b; Transcription; Protein; Expression; Networks; Gene; Perspective; Activation
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 24, Heft: 6, Seiten: , Artikelnummer: 26 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503800-001
Förderungen Universita Politecnica delle Marche, Italy (RSA)
Italian Ministry of Health
DOI 10.3390/ijms24065123
WOS ID 000958778500001
Scopus ID 85151113117
PubMed ID 36982191
Erfassungsdatum 2023-10-06
[➜Korrektur melden]