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Pecori, F. ; Torres-Padilla, M.E.

Dynamics of nuclear architecture during early embryonic development and lessons from liveimaging.

Dev. Cell 58, 435-449 (2023)
Postprint DOI PMC
Open Access Green
Nuclear organization has emerged as a potential key regulator of genome function. During development, the deployment of transcriptional programs must be tightly coordinated with cell division and is often accompanied by major changes in the repertoire of expressed genes. These transcriptional and developmental events are paralleled by changes in the chromatin landscape. Numerous studies have revealed the dynamics of nuclear organization underlying them. In addition, advances in live-imaging-based methodologies enable the study of nuclear organization with high spatial and temporal resolution. In this Review, we summarize the current knowledge of the changes in nuclear architecture in the early embryogenesis of various model systems. Furthermore, to highlight the importance of integrating fixed-cell and live approaches, we discuss how different live-imaging techniques can be applied to examine nuclear processes and their contribution to our understanding of transcription and chromatin dynamics in early development. Finally, we provide future avenues for outstanding questions in this field.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Chromatin ; Embryo ; Epigenetics ; Imaging ; Nuclear Organization; Green Fluorescent Protein; Chromatin Architecture; Chromosome Domains; General-method; Dna-sequences; X-chromosome; Human Genome; Live-cell; Transcription; Organization
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 1534-5807
e-ISSN 1878-1551
Zeitschrift Developmental Cell
Quellenangaben Band: 58, Heft: 6, Seiten: 435-449 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-506200-001
Förderungen
Humboldt Research Fellowship for Postdoctoral Researchers
NIH 4DN program
German Research Foundation (DFG)
Helmholtz Association
DOI 10.1016/j.devcel.2023.02.018
WOS ID 000969894900001
Scopus ID 85150336139
PubMed ID 36977375
Erfassungsdatum 2023-10-06
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