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Wissmiller, K. ; Bilekova, S. ; Frankó, A. ; Lutz, S.Z.* ; Katsburg, M. ; Gulde, S. ; Pellegata, N.S. ; Stenzl, A.* ; Heni, M. ; Berti, L. ; Häring, H.-U. ; Lickert, H.

Inceptor correlates with markers of prostate cancer progression and modulates insulin/IGF1 signaling and cancer cell migration.

Mol. Metab. 71:101706 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
OBJECTIVE: The insulin/insulin-like growth factor 1 (IGF1) pathway is emerging as a crucial component of prostate cancer progression. Therefore, we investigated the role of the novel insulin/IGF1 signaling modulator inceptor in prostate cancer. METHODS: We analyzed the expression of inceptor in human samples of benign prostate epithelium and prostate cancer. Further, we performed signaling and functional assays using prostate cancer cell lines. RESULTS: We found that inceptor was expressed in human benign and malignant prostate tissue and its expression positively correlated with various genes of interest, including genes involved in androgen signaling. In vitro, total levels of inceptor were increased upon androgen deprivation and correlated with high levels of androgen receptor in the nucleus. Inceptor overexpression was associated with increased cell migration, altered IGF1R trafficking and higher IGF1R activation. CONCLUSIONS: Our in vitro results showed that inceptor expression was associated with androgen status, increased migration, and IGF1R signaling. In human samples, inceptor expression was significantly correlated with markers of prostate cancer progression. Taken together, these data provide a basis for investigation of inceptor in the context of prostate cancer.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Androgen ; Igf1r ; Insulin ; Signaling ; Trafficking; Growth-factor-i; Diet-induced Hyperinsulinemia; Androgen Receptor Gene; Membrane Antigen; Neuroendocrine Differentiation; Expression; Activation; Inhibition; Mortality; Estrogen
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2212-8778
e-ISSN 2212-8778
Zeitschrift Molecular Metabolism
Quellenangaben Band: 71, Heft: , Seiten: , Artikelnummer: 101706 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Regeneration Research (IDR)
Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Diabetes and Cancer (IDC)
POF Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502300-001
G-501900-231
G-502400-001
G-502590-001
DOI 10.1016/j.molmet.2023.101706
WOS ID 001026436500001
Scopus ID 85151014669
PubMed ID 36931467
Erfassungsdatum 2023-10-06
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