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Mueller-Peltzer, K.* ; von Krüchten, R.* ; Lorbeer, R.* ; Rospleszcz, S. ; Schulz, H. ; Peters, A. ; Bamberg, F.* ; Schlett, C.L.* ; Mujaj, B.*

Adipose tissue is associated with kidney function parameters.

Sci. Rep. 13:9151 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Obesity is characterized by the accumulation of adipose tissue in different body compartments. Whether adipose tissue directly affects kidney function is still unknown. We aimed to investigate the role of the adipose tissue and circulating creatinine, cystatin C and kidney function in subjects free of cardio-renal diseases. In the KORA-MRI population-based study, 377 subjects (mean age 56.2 ± 9.2 years; 41.6% female) underwent whole-body 3T-MRI examination. Adipose tissue defined as visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were quantified from T1-DIXON sequence using a semi-automatic algorithm. Serum creatinine and cystatin C were measured using standard laboratory and estimated glomerular filtration rate (e-GFR) was performed based on creatinine (e-GFRcrea), cystatin C (e-GFRcys) and creatinine-cystatin C (e-GFRcc). Linear regression analysis, adjusted for risk factors, was used to investigate the relationship between adipose tissue and circulating creatinine, cystatin C, and kidney function. In multivariate analyses VAT was inversely associated with eGFRcys (ß = - 4.88, p =  < 0.001), and positively associated with serum cystatin C (ß = 0.05, p =  < 0.001), respectively. No association was found between other adipose parameters such as total adipose tissue (TAT) and subcutaneous adipose tissue (SAT) and serum creatinine, urine microalbumin and eGFRcrea. Stratified analyses according to BMI revealed confirmatory results for category of BMI > 30. VAT is positively associated with serum cystatin C and inversely with eGFR based on cystatin C, suggesting a direct involvement of visceral adipose tissue in increased metabolism of cystatin C and consequently decreased kidney function.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Glomerular-filtration-rate; Serum Cystatin C; Metabolic Risk; Hypertension; Creatinine; Obesity; Population; Uromodulin; Equations; Ckd
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 13, Heft: 1, Seiten: , Artikelnummer: 9151 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504090-001
G-504000-010
G-504000-009
Förderungen German Centre for Cardiovascular Disease Research (DZHK, Berlin, Germany)
German Centre for Diabetes Research (DZD, Neuherberg Germany)
German Research Foundation (DFG, Bonn, Germany)
State of Bavaria
German Federal Ministry of Education and Research (BMBF)
Helmholtz Zentrum Muenchen-German Research Center for Environmental Health
Projekt DEAL
DOI 10.1038/s41598-023-36390-z
WOS ID 001007425500030
Scopus ID 85161118497
PubMed ID 37280396
Erfassungsdatum 2023-10-06
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