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Kalgudde Gopal, S. ; Dai, R. ; Stefanska, A.M. ; Ansari, M. ; Zhao, J. ; Ramesh, P. ; Bagnoli, J.W.* ; Correa-Gallegos, D. ; Lin, Y. ; Christ, S. ; Angelidis, I. ; Lupperger, V. ; Marr, C. ; Davies, L.C.* ; Enard, W.* ; Machens, H.G.* ; Schiller, H. ; Jiang, D. ; Rinkevich, Y.

Wound infiltrating adipocytes are not myofibroblasts.

Nat. Commun. 14:3020 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The origins of wound myofibroblasts and scar tissue remains unclear, but it is assumed to involve conversion of adipocytes into myofibroblasts. Here, we directly explore the potential plasticity of adipocytes and fibroblasts after skin injury. Using genetic lineage tracing and live imaging in explants and in wounded animals, we observe that injury induces a transient migratory state in adipocytes with vastly distinct cell migration patterns and behaviours from fibroblasts. Furthermore, migratory adipocytes, do not contribute to scar formation and remain non-fibrogenic in vitro, in vivo and upon transplantation into wounds in animals. Using single-cell and bulk transcriptomics we confirm that wound adipocytes do not convert into fibrogenic myofibroblasts. In summary, the injury-induced migratory adipocytes remain lineage-restricted and do not converge or reprogram into a fibrosing phenotype. These findings broadly impact basic and translational strategies in the regenerative medicine field, including clinical interventions for wound repair, diabetes, and fibrotic pathologies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cells; Fibroblasts; Fibrosis; Regeneration; Transition; Mechanisms; Expression; Repair; Tissue
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 3020 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology and Medicine (IRBM)
Institute of Lung Health and Immunity (LHI)
German Center for Lung Research (DZL)
Institute of AI for Health (AIH)
POF Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
30205 - Bioengineering and Digital Health
Forschungsfeld(er) Lung Research
Enabling and Novel Technologies
PSP-Element(e) G-509400-001
G-501693-001
G-501800-810
G-540007-001
Förderungen European Union
Helmholtz Association
German Center for Lung Research (DZL)
European Research Council
Else-Kroener-Fresenius-Stiftung
Fritz-Thyssen-Stiftung
German Research Foundation
Human Frontier Science Program Career Development Award
DOI 10.1038/s41467-023-38591-6
WOS ID 001001080600019
Scopus ID 85160228373
PubMed ID 37230982
Erfassungsdatum 2023-10-06
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