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Grashei, M.* ; Wodtke, P.* ; Skinner, J.G.* ; Sühnel, S.* ; Setzer, N.* ; Metzler, T.* ; Gulde, S. ; Park, M.* ; Witt, D.* ; Mohr, H. ; Hundshammer, C.* ; Strittmatter, N.* ; Pellegata, N.S. ; Steiger, K.* ; Schilling, F.*

Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD.

Nat. Commun. 14:5060 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
pH alterations are a hallmark of many pathologies including cancer and kidney disease. Here, we introduce [1,5-13C2]Z-OMPD as a hyperpolarized extracellular pH and perfusion sensor for MRI which allows to generate a multiparametric fingerprint of renal disease status and to detect local tumor acidification. Exceptional long T1 of two minutes at 1 T, high pH sensitivity of up to 1.9 ppm per pH unit and suitability of using the C1-label as internal frequency reference enables pH imaging in vivo of three pH compartments in healthy rat kidneys. Spectrally selective targeting of both 13C-resonances enables simultaneous imaging of perfusion and filtration in 3D and pH in 2D within one minute to quantify renal blood flow, glomerular filtration rates and renal pH in healthy and hydronephrotic kidneys with superior sensitivity compared to clinical routine methods. Imaging multiple biomarkers within a single session renders [1,5-13C2]Z-OMPD a promising new hyperpolarized agent for oncology and nephrology.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Rat-kidney; Asymmetrical Dimethylarginine; Mri; Gfr; Pheochromocytoma; Autoregulation; Acidification; Biochemistry; Gadolinium; Isoflurane
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 5060 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502590-001
Förderungen
German Federal Ministry of Education and Research (BMBF)
European Union
Young Academy of the Bavarian Academy of Sciences and Humanities
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
DOI 10.1038/s41467-023-40747-3
WOS ID 001053537800018
Scopus ID 85168491903
PubMed ID 37604826
Erfassungsdatum 2023-10-06
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