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Pham, T.C.P.* ; Dollet, L.* ; Ali, M.S.* ; Raun, S.H.* ; Møller, L.L.V.* ; Jafari, A.* ; Ditzel, N.* ; Andersen, N.R.* ; Fritzen, A.M.* ; Gerhart-Hines, Z.* ; Kiens, B.* ; Suomalainen, A.* ; Simpson, S.J.* ; Salling Olsen, M.* ; Kieser, A. ; Schjerling, P.* ; Nieminen, A.I.* ; Richter, E.A.* ; Havula, E.* ; Sylow, L.*

TNIK is a conserved regulator of glucose and lipid metabolism in obesity.

Sci. Adv. 9:eadf7119 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Obesity and type 2 diabetes (T2D) are growing health challenges with unmet treatment needs. Traf2- and NCK-interacting protein kinase (TNIK) is a recently identified obesity- and T2D-associated gene with unknown functions. We show that TNIK governs lipid and glucose homeostasis in Drosophila and mice. Loss of the Drosophila ortholog of TNIK, misshapen, altered the metabolite profiles and impaired de novo lipogenesis in high sugar-fed larvae. Tnik knockout mice exhibited hyperlocomotor activity and were protected against diet-induced fat expansion, insulin resistance, and hepatic steatosis. The improved lipid profile of Tnik knockout mice was accompanied by enhanced skeletal muscle and adipose tissue insulin-stimulated glucose uptake and glucose and lipid handling. Using the T2D Knowledge Portal and the UK Biobank, we observed associations of TNIK variants with blood glucose, HbA1c, body mass index, body fat percentage, and feeding behavior. These results define an untapped paradigm of TNIK-controlled glucose and lipid metabolism.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Skeletal-muscle; Adipose-tissue; Insulin Sensitivity; Resistance; Pathway; Family; Member; Roles; Ampk
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Zeitschrift Science Advances
Quellenangaben Band: 9, Heft: 32, Seiten: , Artikelnummer: eadf7119 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington, DC [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Signaling and Translation (SAT)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-509800-004
Förderungen Independent Research Fund Denmark
European Union's Horizon 2020 research and innovation programme, Marie Sklodowska-Curie
Finnish Diabetes Research Foundation
Novo Nordisk Foundation
Maud Kuistila Foundation
German Research Foundation, Collaborative Research Center
Lundbeck Foundation
Academy of Finland
Sigrid Juselius Foundation
Jane and Aatos Erkko Foundation
Hallas-Moller Emerging Investigator Novo Nordisk Foundation
Orion Research Foundation
DOI 10.1126/sciadv.adf7119
WOS ID 001045489300005
Scopus ID 85167529988
PubMed ID 37556547
Erfassungsdatum 2023-10-06
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