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Lee, C.S.K. ; Weiß, M. ; Hamperl, S.

Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes.

Nucleus 14:2229642 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication named origins are dispersed across each of the linear chromosomes. During S-phase, only a subset of origins is selected in a stochastic manner to assemble bidirectional replication forks and initiate DNA synthesis. Despite substantial progress in our understanding of this complex process, a comprehensive 'identity code' that defines origins based on specific nucleotide sequences, DNA structural features, the local chromatin environment, or 3D genome architecture is still missing. In this article, we review the genetic and epigenetic features of replication origins in yeast and metazoan chromosomes and highlight recent insights into how this flexibility in origin usage contributes to nuclear organization, cell growth, differentiation, and genome stability.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter 3d Genome Organization ; Dna Replication ; Chromatin Structure ; Histone Modifications ; Origin Clustering ; Origins Of Replication ; Replication Timing; Protein Phosphatase 1; Lagging-strand Synthesis; Site-specific Initiation; G-quadruplex Binding; Saccharomyces-cerevisiae; Nucleosome Occupancy; Modulates Replication; Chromatin-structure; Dynamic Changes; Timing Program
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 1949-1034
e-ISSN 1949-1042
Zeitschrift Nucleus
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 2229642 Supplement: ,
Verlag Taylor & Francis
Verlagsort 530 Walnut Street, Ste 850, Philadelphia, Pa 19106 Usa
Institut(e) Institute of Epigenetics and Stem Cells (IES)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-554500-001
Förderungen Helmholtz Association
DOI 10.1080/19491034.2023.2229642
WOS ID 001029834500001
Scopus ID 85165223584
PubMed ID 37469113
Erfassungsdatum 2023-10-06
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