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Yunker, A.G.* ; Chakravartti, S.P.* ; Kullmann, S. ; Veit, R. ; Angelo, B.* ; Jann, K.* ; Monterosso, J.R.* ; Page, K.A.*

Sweet taste preference is associated with greater hypothalamic response to glucose and longitudinal weight gain.

Physiol. Behav. 270:114292 (2023)
Verlagsversion DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The hypothalamus has an abundant expression of sweet taste receptors that play a role in glucose sensing and energy homeostasis. Evidence suggests that liking "sweets" can be associated with weight gain, but the relationship between sweet taste preference and hypothalamic regulation of appetite is unknown. This study tested the hypothesis that sweet taste preference is associated with increased hypothalamic activation in response to glucose (a purported neural marker for weight gain risk) and greater longitudinal increases in body mass index (BMI). Fifty-four adults aged 18-35 years with a mean (± SD) BMI of 27.99 ± 5.32 kg/m2 completed the study. Height and weight were measured at baseline and 6-12 months later in a subset of 36 participants. Sweet taste preference was assessed via the Monell 2-series, forced-choice tracking procedure. Arterial spin labeling magnetic resonance imaging was performed before and after oral glucose ingestion to determine hypothalamic blood flow response to glucose. Linear models were used to examine relationships between sweet taste preference and the hypothalamic response to glucose and longitudinal changes in BMI, adjusting for age, sex, and baseline BMI. Sweet taste preference was positively associated with glucose-linked hypothalamic blood flow (beta = 0.017, p = 0.043), adjusted for age, sex and BMI. We also observed a positive association between sweet taste preference and longitudinal change in BMI (beta = 0.088, p = 0.015), adjusted for age, sex and baseline BMI. These findings suggest that heightened sweet taste preference is associated with glucose-linked hypothalamic activation and may be linked to increased susceptibility for weight gain.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Glucose ; Hypothalamus ; Obesity ; Sweet Taste Preference ; Weight Gain; Functional Mri; Obesity; Brain; Ingestion; Beverages; Appetite; Fructose; Receptor; Regions; System
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 0031-9384
e-ISSN 1873-507X
Zeitschrift Physiology & Behavior
Quellenangaben Band: 270, Heft: , Seiten: , Artikelnummer: 114292 Supplement: ,
Verlag Elsevier
Verlagsort The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
Förderungen Southern California Clinical and Translational Science Institute (SC CTSI) through NIH
National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases
DOI 10.1016/j.physbeh.2023.114292
WOS ID 001047606400001
Scopus ID 85165319075
PubMed ID 37442357
Erfassungsdatum 2023-10-06
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