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Tobias, D.K.* ; Merino, J.* ; Ahmad, A.* ; Aiken, C.* ; Benham, J.L.* ; Bodhini, D.* ; Clark, A.L.* ; Colclough, K.* ; Corcoy, R.* ; Cromer, S.J.* ; Duan, D.* ; Felton, J.L.* ; Francis, E.C.* ; Gillard, P.* ; Gingras, V.* ; Gaillard, R.* ; Haider, E.* ; Hughes, A.* ; Ikle, J.M.* ; Jacobsen, L.M.* ; Kahkoska, A.R.* ; Kettunen, J.L.T.* ; Kreienkamp, R.J.* ; Lim, L.L.* ; Männistö, J.M.E.* ; Massey, R.* ; Mclennan, N.M.* ; Miller, R.G.* ; Morieri, M.L.* ; Most, J.* ; Naylor, R.N.* ; Ozkan, B.* ; Patel, K.A.* ; Pilla, S.J.* ; Prystupa, K.* ; Raghavan, S.* ; Rooney, M.R.* ; Schön, M.* ; Semnani-Azad, Z.* ; Sevilla-Gonzalez, M.* ; Svalastoga, P.* ; Takele, W.W.* ; Tam, C.H.T.* ; Thuesen, A.C.B.* ; Tosur, M.* ; Wallace, A.S.* ; Wang, C.C.* ; Wong, J.J.* ; Yamamoto, J.M.* ; Young, K.* ; Amouyal, C.* ; Andersen, M.K.* ; Bonham, M.P.* ; Chen, M.* ; Cheng, F.* ; Chikowore, T.* ; Chivers, S.C.* ; Clemmensen, C.* ; Dabelea, D.* ; Dawed, A.Y.* ; Deutsch, A.J.* ; Dickens, L.T.* ; Dimeglio, L.A.* ; Dudenhöffer-Pfeifer, M.* ; Evans-Molina, C.* ; Fernández-Balsells, M.M.* ; Fitipaldi, H.* ; Fitzpatrick, S.L.* ; Gitelman, S.E.* ; Goodarzi, M.O.* ; Grieger, J.A.* ; Guasch-Ferré, M.* ; Habibi, N.* ; Hansen, T.* ; Huang, C.* ; Harris-Kawano, A.* ; Ismail, H.M.* ; Hoag, B.* ; Johnson, R.K.* ; Jones, A.G.* ; Koivula, R.W.* ; Leong, A.* ; Leung, G.K.W.* ; Libman, I.M.* ; Liu, K.* ; Long, S.A.* ; Lowe, W.L.* ; Morton, R.W.* ; Motala, A.A.* ; Onengut-Gumuscu, S.* ; Pankow, J.S.* ; Pathirana, M.* ; Pazmino, S.* ; Perez, D.* ; Petrie, J.R.* ; Powe, C.E.* ; Quinteros, A.* ; Jain, R.* ; Ray, D.* ; Ried-Larsen, M.* ; Stefan, N. ; Franks, P.W.*

Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.

Nat. Med. 29, 2438-2457 (2023)
Postprint DOI PMC
Open Access Green
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Coronary-artery-disease; Complications Trial/epidemiology; Risk-factors; Glycemic Control; Interventions; Neuropathy
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 1078-8956
e-ISSN 1546-170X
Zeitschrift Nature medicine
Quellenangaben Band: 29, Heft: 10, Seiten: 2438-2457 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
Förderungen Medical Research Council
NICHD NIH HHS
DOI 10.1038/s41591-023-02502-5
WOS ID 001184464000004
WOS ID 001085074500001
Scopus ID 85173437266
PubMed ID 37794253
Erfassungsdatum 2023-10-18
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