PuSH - Publikationsserver des Helmholtz Zentrums München: Antiviral CD8<sup>+</sup>T-cell immune responses are impaired by cigarette smoke and in COPD.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Chen, J. ; Wang, X. ; Schmalen, A. ; Haines, S. ; Wolff, M.* ; Ma, H.* ; Zhang, H.* ; Stoleriu, M.-G. ; Nowak, J. ; Nakayama, M. ; Bueno, M.* ; Brands, J.* ; Mora, A.L.* ; Lee, J.S.* ; Krauss-Etschmann, S.* ; Dmitrieva, A. ; Frankenberger, M. ; Hofer, T.P. ; Nößner, E. ; Moosmann, A.* ; Behr, J.* ; Milger, K.* ; Deeg, C.A.* ; Staab-Weijnitz, C.A. ; Hauck, S.M. ; Adler, H. ; Goldmann, T.* ; Gaede, K.I.* ; Behrends, J.* ; Kammerl, I.E. ; Meiners, S.

Antiviral CD8⁺T-cell immune responses are impaired by cigarette smoke and in COPD.

Eur. Respir. J. 62:16 (2023)

Verlagsversion

DOI

PMC

	Open Access Hybrid

Abstract
Metriken
Zusatzinfos

Background Virus infections drive COPD exacerbations and progression. Antiviral immunity centres on the activation of virus-specific CD8+ T-cells by viral epitopes presented on major histocompatibility complex (MHC) class I molecules of infected cells. These epitopes are generated by the immunoproteasome, a specialised intracellular protein degradation machine, which is induced by antiviral cytokines in infected cells. Methods We analysed the effects of cigarette smoke on cytokine-and virus-mediated induction of the immunoproteasome in vitro, ex vivo and in vivo using RNA and Western blot analyses. CD8+ T-cell activation was determined in co-culture assays with cigarette smoke-exposed influenza A virus (IAV)-infected cells. Mass-spectrometry-based analysis of MHC class I-bound peptides uncovered the effects of cigarette smoke on inflammatory antigen presentation in lung cells. IAV-specific CD8+ T-cell numbers were determined in patients peripheral blood using tetramer technology. Results Cigarette smoke impaired the induction of the immunoproteasome by cytokine signalling and viral infection in lung cells in vitro, ex vivo and in vivo. In addition, cigarette smoke altered the peptide repertoire of antigens presented on MHC class I molecules under inflammatory conditions. Importantly, MHC class I-mediated activation of IAV-specific CD8+ T-cells was dampened by cigarette smoke. COPD patients exhibited reduced numbers of circulating IAV-specific CD8+ T-cells compared to healthy controls and asthmatics. Conclusion Our data indicate that cigarette smoke interferes with MHC class I antigen generation and presentation and thereby contributes to impaired activation of CD8+ T-cells upon virus infection. This adds important mechanistic insight on how cigarette smoke mediates increased susceptibility of smokers and COPD patients to viral infections.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

24.300

3.602

PuSH - Publikationsserver des Helmholtz Zentrums München

Antiviral CD8+T-cell immune responses are impaired by cigarette smoke and in COPD.

Antiviral CD8⁺T-cell immune responses are impaired by cigarette smoke and in COPD.