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Hvidtfeldt, U.A.* ; Chen, J.* ; Rodopoulou, S.* ; Strak, M.* ; de Hoogh, K.* ; Andersen, Z.J.* ; Bellander, T.* ; Brandt, J.* ; Fecht, D.* ; Forastiere, F.* ; Gulliver, J.* ; Hertel, O.* ; Hoffmann, B.* ; Katsouyanni, K.* ; Ketzel, M.* ; Leander, K.* ; Magnusson, P.K.E.* ; Nagel, G.* ; Pershagen, G.* ; Rizzuto, D.* ; Samoli, E.* ; So, R.* ; Stafoggia, M.* ; Tjønneland, A.* ; Weinmayr, G.* ; Wolf, K. ; Zhang, J.* ; Zitt, E.* ; Brunekreef, B.* ; Hoek, G.* ; Raaschou-Nielsen, O.*

Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: A pooled analysis of six European cohorts.

Br. J. Cancer 129, 656-664 (2023)
Postprint DOI PMC
Open Access Green
Background: Risk factors for malignant tumours of the central nervous system (CNS) are largely unknown. Methods: We pooled six European cohorts (N = 302,493) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) and malignant intracranial CNS tumours defined according to the International Classification of Diseases ICD-9/ICD-10 codes 192.1/C70.0, 191.0–191.9/C71.0–C71.9, 192.0/C72.2–C72.5. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. Results: During 5,497,514 person-years of follow-up (average 18.2 years), we observed 623 malignant CNS tumours. The results of the fully adjusted linear analyses showed a hazard ratio (95% confidence interval) of 1.07 (0.95, 1.21) per 10 μg/m³ NO2, 1.17 (0.96, 1.41) per 5 μg/m³ PM2.5, 1.10 (0.97, 1.25) per 0.5 10−5m−1 BC, and 0.99 (0.84, 1.17) per 10 μg/m³ O3. Conclusions: We observed indications of an association between exposure to NO2, PM2.5, and BC and tumours of the CNS. The PM elements were not consistently associated with CNS tumour incidence.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cancer; Risk; Men; Profile; Epidemiology; Completeness; Population; Models; Health; Women
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 0007-0920
e-ISSN 1532-1827
Zeitschrift British Journal of Cancer BJC
Quellenangaben Band: 129, Heft: 4, Seiten: 656-664 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Campus, 4 Crinan St, London, N1 9xw, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-001
Förderungen United States Environmental Protection Agency (EPA)
DOI 10.1038/s41416-023-02348-1
WOS ID 001023988400001
Scopus ID 85164186719
PubMed ID 37420001
Erfassungsdatum 2023-10-18
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