PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Moser, C.* ; Gosselé, K.A.* ; Balaz, M.* ; Balázová, L.* ; Horvath, C.* ; Künzle, P.* ; Okreglicka, K.M.* ; Li, F.* ; Blüher, M. ; Stierstorfer, B.* ; Hess, E.* ; Lamla, T.* ; Hamilton, B.* ; Klein, H.* ; Neubauer, H.* ; Wolfrum, C.* ; Wolfrum, S.*

FAM3D: A gut secreted protein and its potential in the regulation of glucose metabolism.

Peptides 167:171047 (2023)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
The number of diabetic patients is rising globally and concomitantly so do the diabetes associated complications. The gut secretes a variety of proteins to control blood glucose levels and/or food intake. As the drug class of GLP-1 agonists is based on a gut secreted peptide and the positive metabolic effects of bariatric surgery are at least partially mediated by gut peptides, we were interested in other gut secreted proteins which have yet to be explored. In this respect we identified the gut secreted protein FAM3D by analyzing sequencing data from L- and epithelial cells of VSG and sham operated as well as chow and HFD fed mice. FAM3D was overexpressed in diet induced obese mice via an adeno-associated virus (AAV), which resulted in a significant improvement of fasting blood glucose levels, glucose tolerance and insulin sensitivity. The liver lipid deposition was reduced, and the steatosis morphology was improved. Hyperinsulinemic clamps indicated that FAM3D is a global insulin sensitizer and increases glucose uptake into various tissues. In conclusion, the current study demonstrated that FAM3D controls blood glucose levels by acting as an insulin sensitizing protein and improves hepatic lipid deposition.
Impact Factor
Scopus SNIP
Altmetric
3.000
0.783
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Fam3 Family ; Glucose Metabolism ; Gut Secreted Proteins ; Insulin Sensitizer ; Type 2 Diabetes; Tyrosine Kinase Inhibitors; Type-2 Diabetes-mellitus; Insulin Sensitivity; Pathway; Drugs
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 0196-9781
e-ISSN 1873-5169
Zeitschrift Peptides
Quellenangaben Band: 167, Heft: , Seiten: , Artikelnummer: 171047 Supplement: ,
Verlag Elsevier
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-506501-001
Förderungen SNF
DOI 10.1016/j.peptides.2023.171047
WOS ID 001044137900001
Scopus ID 85163474331
PubMed ID 37328068
Erfassungsdatum 2023-10-18
[➜Korrektur melden]