PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Slieker, R.C.* ; Donnelly, L.A.* ; Akalestou, E.* ; Lopez-Noriega, L.* ; Melhem, R.* ; Güneş, A.* ; Abou Azar, F.* ; Efanov, A.* ; Georgiadou, E.* ; Muniangi-Muhitu, H.* ; Sheikh, M.* ; Giordano, G.N.* ; Åkerlund, M.* ; Ahlqvist, E.* ; Ali, A.* ; Banasik, K.* ; Brunak, S.* ; Barovic, M. ; Bouland, G.A.* ; Burdet, F.* ; Canouil, M.* ; Dragan, I.* ; Elders, P.J.M.* ; Fernandez, C.* ; Festa, A.* ; Fitipaldi, H.* ; Froguel, P.* ; Gudmundsdottir, V.* ; Gudnason, V.* ; Gerl, M.J.* ; van der Heijden, A.A.* ; Jennings, L.L.* ; Hansen, M.K.* ; Kim, M.* ; Leclerc, I.* ; Klose, C.* ; Kuznetsov, D.* ; Mansour Aly, D.* ; Mehl, F.* ; Marek, D.* ; Melander, O.* ; Niknejad, A.* ; Ottosson, F.* ; Pavo, I.* ; Duffin, K.C.* ; Syed, S.K.* ; Shaw, J.L.* ; Cabrera, O.* ; Pullen, T.J.* ; Simons, K.* ; Solimena, M. ; Suvitaival, T.* ; Wretlind, A.* ; Rossing, P.* ; Lyssenko, V.* ; Legido Quigley, C.* ; Groop, L.* ; Thorens, B.* ; Franks, P.W.* ; Lim, G.E.* ; Estall, J.* ; Ibberson, M.* ; Beulens, J.W.J.* ; ’t Hart, L.M.* ; Pearson, E.R.* ; Rutter, G.A.*

Identification of biomarkers for glycaemic deterioration in type 2 diabetes.

Nat. Commun. 14:2533 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol species, and lowered sphingomyelin 42:2;2 levels are predictive of faster progression towards insulin requirement. Of ~1,300 proteins examined in two cohorts, levels of GDF15/MIC-1, IL-18Ra, CRELD1, NogoR, FAS, and ENPP7 are associated with faster progression, whilst SMAC/DIABLO, SPOCK1 and HEMK2 predict lower progression rates. In an external replication, proteins and lipids are associated with diabetes incidence and prevalence. NogoR/RTN4R injection improved glucose tolerance in high fat-fed male mice but impaired it in male db/db mice. High NogoR levels led to islet cell apoptosis, and IL-18R antagonised inflammatory IL-18 signalling towards nuclear factor kappa-B in vitro. This comprehensive, multi-disciplinary approach thus identifies biomarkers with potential prognostic utility, provides evidence for possible disease mechanisms, and identifies potential therapeutic avenues to slow diabetes progression.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Altmetric
16.600
0.000
1
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter 2-aminoadipic Acid; Obese Women; Weight-loss; Protein; Receptor; Expression; Homocitrulline; Association; Deficiency; Metabolism
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 2533 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-001
Förderungen Faculty of Medicine at Lund University
Swedish Research Council
Swedish Foundation for Strategic Research
Wellcome Trust New Investigator Award
Wellcome Trust Investigator Award
MRC
Experimental Challenge Grant (DIVA)
Diabetes UK Project
Canada Research Chair in Adipocyte Development
Swedish governmental funding of clinical research (ALF)
Vinnova Swelife
Innovative Medicines Initiative 2 Joint Undertaking
Innovation Canada
European Union
EFPIA
Swiss State Secretariat for Education, Research and Innovation (SERI)
Icelandic Research Fund
Netherlands Organisation for Health Research and Development
CIHR
Wellcome Trust
CIHR Project Grant
DOI 10.1038/s41467-023-38148-7
WOS ID 001025265700001
Scopus ID 85158018722
PubMed ID 37137910
Erfassungsdatum 2023-11-27
[➜Korrektur melden]