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Su, X.* ; Chen, S.* ; Liu, J.* ; Feng, Y.* ; Han, E.* ; Hao, X.* ; Liao, M. ; Cai, J.* ; Zhang, S.* ; Niu, J.* ; He, S.* ; Huang, S.* ; Lo, K.* ; Zeng, F.*

Composition of gut microbiota and non-alcoholic fatty liver disease: A systematic review and meta-analysis.

Obes. Rev. 25:e13646 (2024)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The present systematic review and meta-analysis aimed to summarize the associations between gut microbiota composition and non-alcoholic fatty liver disease. To compare the differences between individuals with or without NAFLD, the standardized mean difference and 95% confidence interval were computed for each α-diversity index and relative abundance of gut microbes. The β-diversity indices were summarized in a qualitative manner. A total of 54 studies with 8894 participants were included. Overall, patients with NAFLD had moderate reduction in α-diversity indices including Shannon (SMD = -0.36, 95% CI = [-0.53, -0.19], p < 0.001) and Chao 1 (SMD = -0.42, 95% CI = [-0.68, -0.17], p = 0.001), but no significant differences were found for Simpson, observed species, phylogenetic diversity, richness, abundance-based coverage estimator, and evenness (p ranged from 0.081 to 0.953). Over 75% of the included studies reported significant differences in β-diversity. Although there was substantial interstudy heterogeneity, especially for analyses at the phylum, class, and family levels, the majority of the included studies showed alterations in the depletion of anti-inflammatory microbes (i.e., Ruminococcaceae and Coprococcus) and the enrichment of proinflammatory microbes (i.e., Fusobacterium and Escherichia) in patients with NAFLD. Perturbations in gut microbiota were associated with NAFLD, commonly reflected by a reduction in beneficial species and an increase in the pathogenic species.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Gut Microbiota ; Meta-analysis ; Non-alcoholic Fatty Liver ; Systematic Review; Fusobacterium-nucleatum; Fecal Microbiota; Receptor; Steatohepatitis; Inflammation; Dysbiosis; Butyrate; Ethanol; Obesity; Il-17
Sprache englisch
Veröffentlichungsjahr 2024
Prepublished im Jahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 1467-7881
e-ISSN 1467-789X
Zeitschrift Obesity Reviews
Quellenangaben Band: 25, Heft: 1, Seiten: , Artikelnummer: e13646 Supplement: ,
Verlag Blackwell
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-001
Förderungen National Natural Science Foundation of China
Guangdong Basic and Applied Basic Research Foundation
This research was supported by grants from Guangdong Basic and Applied Basic Research Foundation (2023A1515030155, Z.F.F.) and National Natural Science Foundation of China (81602853, Z.F.F.).
DOI 10.1111/obr.13646
WOS ID 001081105000001
Scopus ID 85173777193
PubMed ID 37813400
Erfassungsdatum 2023-11-28
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