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Kos, A.* ; Lopez, J.P.* ; Bordes, J.* ; De Donno, C. ; Dine, J.* ; Brivio, E.* ; Karamihalev, S.* ; Luecken, M. ; Almeida-Correa, S.* ; Gasperoni, S.* ; Dick, A.* ; Miranda, L.* ; Büttner, M. ; Stoffel, R.* ; Flachskamm, C.* ; Theis, F.J. ; Schmidt, M.V.* ; Chen, A.*

Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus.

Sci. Adv. 9:eadj3793 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Adverse events in early life can modulate the response to additional stressors later in life and increase the risk of developing psychiatric disorders. The underlying molecular mechanisms responsible for these effects remain unclear. Here, we uncover that early life adversity (ELA) in mice leads to social subordination. Using single-cell RNA sequencing (scRNA-seq), we identified cell type-specific changes in the transcriptional state of glutamatergic and GABAergic neurons in the ventral hippocampus of ELA mice after exposure to acute social stress in adulthood. These findings were reflected by an alteration in excitatory and inhibitory synaptic transmission induced by ELA in response to acute social stress. Finally, enhancing the inhibitory network function through transient diazepam treatment during an early developmental sensitive period reversed the ELA-induced social subordination. Collectively, this study significantly advances our understanding of the molecular, physiological, and behavioral alterations induced by ELA, uncovering a previously unknown cell type-specific vulnerability to ELA.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Adult Neurogenesis; Stress; Expression; Abuse; Exposure; Amygdala; Model; Brain; Consequences; Persistence
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Zeitschrift Science Advances
Quellenangaben Band: 9, Heft: 48, Seiten: , Artikelnummer: eadj3793 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington, DC [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30205 - Bioengineering and Digital Health
30202 - Environmental Health
Forschungsfeld(er) Enabling and Novel Technologies
Lung Research
PSP-Element(e) G-503800-001
G-505000-008
Förderungen Adelis Foundation
Perlman Family Foundation
Bruno and Simone Licht
Ruhman Family Laboratory for Research on the Neurobiology of Stress
European Union
Canadian Biomarker Integration Network in Depression(CAN-BIND)
Alexandervon Humboldt Foundation
European Molecular Biology Organization
DOI 10.1126/sciadv.adj3793
WOS ID 001120198200013
Scopus ID 85178365540
PubMed ID 38039370
Erfassungsdatum 2023-12-18
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