PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Sun, C.* ; Holstein, D.J.F.* ; Garcia-Cubero, N.* ; Moulla, Y.* ; Stroh, C.* ; Dietrich, A.* ; Schön, M.R.* ; Gärtner, D.* ; Lohmann, T.* ; Dressler, M.* ; Stumvoll, M. ; Blüher, M. ; Kovacs, P.* ; Guiu-Jurado, E.*

The role of phosphatidylethanolamine N-methyltransferase (PEMT) and its waist-hip-ratio-associated locus rs4646404 in obesity-related metabolic Traits and liver disease.

Int. J. Mol. Sci. 24:16850 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
In previous genome-wide association studies (GWAS), genetic loci associated with obesity and impaired fat distribution (FD) have been identified. In the present study, we elucidated the role of the PEMT gene, including the waist-hip-ratio-associated single nucleotide polymorphism rs4646404, and its influence on obesity-related metabolic traits. DNA from 2926 metabolically well-characterized subjects was used for genotyping. PEMT expression was analyzed in paired visceral (vis) and subcutaneous (sc) adipose tissue (AT) from a subset of 574 individuals. Additionally, PEMT expression was examined in vis, sc AT and liver tissue in a separate cohort of 64 patients with morbid obesity and liver disease. An in vitro Pemt knockdown was conducted in murine epididymal and inguinal adipocytes. Our findings highlight tissue-specific variations in PEMT mRNA expression across the three studied tissues. Specifically, vis PEMT mRNA levels correlated significantly with T2D and were implicated in the progression of non-alcoholic steatohepatitis (NASH), in contrast to liver tissue, where no significant associations were found. Moreover, sc PEMT expression showed significant correlations with several anthropometric- and metabolic-related parameters. The rs4646404 was associated with vis AT PEMT expression and also with diabetes-related traits. Our in vitro experiments supported the influence of PEMT on adipogenesis, emphasizing its role in AT biology. In summary, our data suggest that PEMT plays a role in regulating FD and has implications in metabolic diseases.
Impact Factor
Scopus SNIP
Altmetric
5.600
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Pemt ; Adipose Tissue ; Fat Distribution ; Liver Disease ; Obesity ; Rs4646404; S-adenosylmethionine; Phosphatidylcholine; Adipose; Weight
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 24, Heft: 23, Seiten: , Artikelnummer: 16850 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-506500-001
G-506501-001
Förderungen China Scholarship Council
DOI 10.3390/ijms242316850
WOS ID 001117614100001
Scopus ID 85179338211
PubMed ID 38069170
Erfassungsdatum 2023-12-19
[➜Korrektur melden]